Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study
文献类型：期刊论文
| 作者 | Weipan Xu ; Huaqiong Bao ; Feng Liu ; Liangpo Liu ; Yongguan Zhu ; Jianwen She ; Sijun Dong ; Min Cai ; Lianbing Li ; Chuanhai Li ; Heqing Shen |
| 刊名 | Environmental Health
 |
| 出版日期 | 2012 |
| 卷号 | 11期号:/页码:46 |
| 英文摘要 | Background: Recent observations in in vitro and in vivo models suggest that arsenic (As) is an endocrine disruptor at environmentally-relevant levels. When exposed to As, male rats and mice show steroidogenic dysfunction that can lead to infertility. However, the possible effects of As on human male semen quality remain obscure. Methods: We monitored the profile of As species in the urine of a reproductive-age human cohort and assessed its association with semen quality. Men (n = 96) were recruited in an infertility clinic from July 2009 to August 2010 in the Affiliated Hospital of Chongqing Institute for Population and Family Planning. Five urinary As species were analyzed by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Clinical information on the semen volume, sperm concentration and motility was employed to catalogue and evaluate semen quality according to WHO guidelines. As species concentrations in addition to other continuous variables were dichotomized by the medians and modelled as categorical variables in order to explore using the binary logistic regression possible associations between As exposure and semen quality. Results: Urinary concentrations (geometric mean ± SD, μg g-1 creatinine) of different As species were 7.49 (±24.8) for AsB, 20.9 (±13.7) for DMA, 2.77 (±3.33) for MMA, and 4.03 (±3.67) for Asi (AsiIII and AsiV). DMA concentrations above the median were significantly associated with below-reference sperm concentrations (P =0.02) after adjusting for age, body mass index (BMI), abstinence, smoking and drinking habits. In addition, smoking was positively associated with MMA. Conclusion: Reduced parameters in human semen quality are positively associated with As exposure in a reproductiveage Chinese cohort. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://124.16.167.195/handle/335003/1173]  |
| 专题 | 城市环境研究所_城市土壤与生物地球化学研究组_期刊论文 |
| 推荐引用方式 GB/T 7714 | Weipan Xu,Huaqiong Bao,Feng Liu,et al. Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study[J]. Environmental Health,2012,11(/):46. |
| APA | Weipan Xu.,Huaqiong Bao.,Feng Liu.,Liangpo Liu.,Yongguan Zhu.,...&Heqing Shen.(2012).Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study.Environmental Health,11(/),46. |
| MLA | Weipan Xu,et al."Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study".Environmental Health 11./(2012):46. |
入库方式： OAI收割
来源：城市环境研究所
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