PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner
文献类型：期刊论文
| 作者 | Fang Chao ; Wu Xinlong ; Huang Qiansheng ; Liao Yanyan ; Liu Liangpo ; Qiu ling ; Dong Sijun |
| 刊名 | Aquatic Toxicology
 |
| 出版日期 | 2012 |
| 卷号 | 106-107期号:15页码:9-19 |
| 中文摘要 | Perfluorooctane sulfonate (PFOS) is widely distributed in seawater. However, the effects of PFOS on important receptors involved in the toxicity of POPs have not been fully defined, especially for the embryonic stages of marine fish. In this study, we examined the transcriptional responses and PFOS accumulation in the marine medaka embryos at the early and late developmental stages of 4 and 10 dpf upon PFOS exposure (1, 4, and 16 mg/L). PFOS accumulated in the embryos, and the embryonic burdens of PFOS at 10 dpf were markedly higher than those at 4 dpf. Moreover, thirteen genes involved in three important POPs-related receptor pathways, including ER, AHR and PPAR, were cloned and investigated. The mRNA expression levels of ER and ER were not significantly altered, but the estrogenic marker genes were downregulated upon PFOS exposure at 4 dpf. Conversely, ERs and related marker genes all were significantly upregulated at 10 dpf. The expressions of ARNT and cyp1a were both upregulated at 4 dpf, while no obvious changes were detected at 10 dpf. The expressions of cyp19a and cyp19b were regulated by PFOS in a stage-specific manner. PFOS produced different effects on three isoforms of PPAR. PPAR and PPAR were first inhibited at 4 dpf and were induced at 10 dpf. PFOS did not elicit a change in PPAR expression at either stage. In conclusion, this study showed that PFOS has an estrogenic activity and endocrinedisruptive properties. Meanwhile, PFOS could elicit transcriptional responses on POPs-related pathways in a stage-specific manner. |
| 收录类别 | SCI |
| 公开日期 | 2013-08-30 |
| 源URL | [http://124.16.167.195/handle/335003/1195]  |
| 专题 | 城市环境研究所_环境医学和分子毒理研究组_期刊论文 |
| 推荐引用方式 GB/T 7714 | Fang Chao,Wu Xinlong,Huang Qiansheng,et al. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner[J]. Aquatic Toxicology,2012,106-107(15):9-19. |
| APA | Fang Chao.,Wu Xinlong.,Huang Qiansheng.,Liao Yanyan.,Liu Liangpo.,...&Dong Sijun.(2012).PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner.Aquatic Toxicology,106-107(15),9-19. |
| MLA | Fang Chao,et al."PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner".Aquatic Toxicology 106-107.15(2012):9-19. |
入库方式： OAI收割
来源：城市环境研究所
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