PFOS induced precocious hatching of Oryzias melastigma–From molecular level
文献类型：期刊论文
| 作者 | Wu Xinlong ; Huang Qiansheng ; Fang Chao ; Dong Sijun |
| 刊名 | Chemosphere
 |
| 出版日期 | 2012 |
| 卷号 | 87期号:7页码:703-708 |
| 中文摘要 | Perfluorooctane sulfonate (PFOS) showed a risk of causing adverse effects including hatching of animals.However, there are no systematical studies about the effects of PFOS on fish embryo hatching. In this study, a precocious hatching was detected in Oryzias melastigma embryos upon PFOS exposure. The average hatching time was shortened and the hatching rate increased after PFOS exposure. The subsequent survival rate decreased significantly in the larvae hatching from the PFOS-treated embryos compared to the control. The influence occurred in a PFOS concentration-dependent manner. To further elucidate the inner molecular change, full length cDNAs of hatching enzymes HCE and LCE were first cloned in O. melastigma by degenerate RT-PCR and RACE. PFOS elicited a transcriptional response of both HCE and LCE. The expressions of both genes were significantly up-regulated earlier in the PFOS-treated group than in the control group. The activity of hatching enzyme also significantly increased upon exposure. In all, our results showed that exposure to PFOS could induce the hatching enzyme both at transcriptional and enzymatic activity level and further lead to the precocious hatching of O. melastigma embryos, which induced the decrease of the subsequent larvae survival. |
| 收录类别 | SCI |
| 公开日期 | 2013-08-30 |
| 源URL | [http://124.16.167.195/handle/335003/1196]  |
| 专题 | 城市环境研究所_环境医学和分子毒理研究组_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu Xinlong,Huang Qiansheng,Fang Chao,et al. PFOS induced precocious hatching of Oryzias melastigma–From molecular level[J]. Chemosphere,2012,87(7):703-708. |
| APA | Wu Xinlong,Huang Qiansheng,Fang Chao,&Dong Sijun.(2012).PFOS induced precocious hatching of Oryzias melastigma–From molecular level.Chemosphere,87(7),703-708. |
| MLA | Wu Xinlong,et al."PFOS induced precocious hatching of Oryzias melastigma–From molecular level".Chemosphere 87.7(2012):703-708. |
入库方式： OAI收割
来源：城市环境研究所
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