The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice
文献类型：期刊论文
| 作者 | Jie Zhang ; Lijuan Yan ; Meiping Tian ; Qiansheng Huang ; Siyuan Peng ; Sijun Dong |
| 刊名 | Journal of Pharmaceutical and Biomedical Analysis
 |
| 出版日期 | 2012 |
| 卷号 | 66期号:/页码:287-297 |
| 中文摘要 | Humans undergo simultaneous daily exposure to a multitude of endocrine-disrupting compounds (EDCs).In present study, after combined exposure to endocrine disruptors DEHP and Aroclor 1254 for 12 days, a iquid chromatography/time-of-flight mass spectrometer method combining both reversed-phase (RP) and hydrophilic interaction chromatography (HILIC) separations was carried out to investigate the etabolic responses in mice. The metabolic profiles of endogenous metabolites could differentiate the ose and control groups in both RPLC and HILIC modes. Moreover, the male mice and female mice in different groups could be obviously clustered in their own regions with combined model. Fourteen lysoPCs,PC(18:4/18:1), lysoPE(18:2/0:0), phenylalanine and tryptophan were identified as potential biomarkers or the combined toxicity of DEHP and Aroclor 1254. Different change trends could be observed for the identified lysoPCs, due to their different levels of uptake and metabolism in mice. Moreover, genderspecific ifferences in several lysoPCs (e.g. lysoPC(18:0), lysoPC(22:6), lysoPC(20:3), and PC(18:4/18:1))were observed for treated mice. The metabonomic results indicated the combined exposure led to a disturbance of lipid metabolism. The mRNA expressions of PLA2, ACOX1, CPT1, FAS and SCD1 involved n lipid metabolism were investigated. Among them, significant increases of FAS and SCD1 expressions n the liver induced by the exposure could be observed for both male and female mice, contributing to the hepatic lipid accumulation in mice. Besides lipid metabolism, tryptophan metabolism and phenylalanine etabolism may also be involved with the toxic responses to these EDCs. The present study ot only improves the understanding of the combined toxicity of phthalates and PCBs but also shows hat the etabonomic approach may prove to be a promising technique for the toxicity research of EDCs. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://124.16.167.195/handle/335003/1176]  |
| 专题 | 城市环境研究所_环境污染物的人群暴露与健康效应研究组_期刊论文 |
| 推荐引用方式 GB/T 7714 | Jie Zhang,Lijuan Yan,Meiping Tian,et al. The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice[J]. Journal of Pharmaceutical and Biomedical Analysis,2012,66(/):287-297. |
| APA | Jie Zhang,Lijuan Yan,Meiping Tian,Qiansheng Huang,Siyuan Peng,&Sijun Dong.(2012).The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice.Journal of Pharmaceutical and Biomedical Analysis,66(/),287-297. |
| MLA | Jie Zhang,et al."The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice".Journal of Pharmaceutical and Biomedical Analysis 66./(2012):287-297. |
入库方式： OAI收割
来源：城市环境研究所
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