. Dissecting and engineering metabolic and regulatory networks of thermophilic bacteria for biofuel production
文献类型：期刊论文
| 作者 | Xu, J.
|
| 刊名 | Biotechnology Advance
 |
| 出版日期 | 2013 |
| 卷号 | 31期号:6页码:827-837 |
| 关键词 | Thermophilic bacteria Carbon utilization Stress response Microevolution Genetic |
| 中文摘要 | Interest in thermophilic bacteria as live-cell catalysts in biofuel and biochemical industry has surged in recent years, due to their tolerance of high temperature and wide spectrum of carbon-sources that include cellulose. However their direct employment as microbial cellular factories in the highly demanding industrial conditions has been hindered by uncompetitive biofuel productivity, relatively low tolerance to solvent and osmic stresses, and limitation in genome engineering tools. In this work we reviewrecent advances in dissecting and engineering the metabolic and regulatory networks of thermophilic bacteria for improving the traits of key interest in biofuel industry: cellulose degradation, pentose–hexose co-utilization, and tolerance of thermal, osmotic, and solvent stresses.Moreover, newtechnologies enablingmore efficient genetic engineering of thermophileswere discussed, such as improved electroporation, ultrasound-mediated DNAdelivery, aswellas thermo-stableplasmids andfunctional selection systems. Expanded applications of such technological advancements in thermophilic microbes promise to substantiate a synthetic biology perspective,where functional parts,module, chassis, cells and consortia weremodularly designed and rationally assembled for themanymissions at industry and nature that demand the extraordinary talents of these extremophiles |
| 学科主题 | 功能基因组 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-03-21 |
| 源URL | [http://ir.qibebt.ac.cn:8080/handle/337004/1614]  |
| 专题 | 青岛生物能源与过程研究所_单细胞中心 |
| 推荐引用方式 GB/T 7714 | Xu, J.. . Dissecting and engineering metabolic and regulatory networks of thermophilic bacteria for biofuel production[J]. Biotechnology Advance,2013,31(6):827-837. |
| APA | Xu, J..(2013).. Dissecting and engineering metabolic and regulatory networks of thermophilic bacteria for biofuel production.Biotechnology Advance,31(6),827-837. |
| MLA | Xu, J..". Dissecting and engineering metabolic and regulatory networks of thermophilic bacteria for biofuel production".Biotechnology Advance 31.6(2013):827-837. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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