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  4. 材料生物技术研究中心
Inducible cell lysis systems in microbial production of bio-based chemicals

文献类型：期刊论文

作者Gao, Yongqiang1,3; Feng, Xinjun1,3; Xian, Mo1,2; Wang, Qi1,3; Zhao, Guang1,2
刊名APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
出版日期2013-08-01
卷号97期号:16页码:7121-7129
关键词Cell lysis systems Inducible regulatory apparatus Holin-endolysin system Lipid enzyme system Toxin-antitoxin system
英文摘要The release of products from microbial cells is an essential process for industrial scale production of bio-based chemicals. However, traditional methods of cell lysis, e.g., mechanical disruption, chemical solvent extraction, and immobilized enzyme degradation, account for a large share of the total production cost. Thus, an efficient cell lysis system is required to lower the cost. This review has focused on our current knowledge of two cell lysis systems, bacteriophage holin-endolysin system, and lipid enzyme hydrolysis system. These systems are controlled by conditionally inducible regulatory apparatus and applied in microbial production of fatty acids and polyhydroxyalkanoates. Moreover, toxin-antitoxin system is also suggested as alternative for its potential applications in cell lysis. Compared with traditional methods of cell disruption, the inducible cell lysis systems are more economically feasible and easier to control and show a promising perspective in industrial production of bio-based chemicals.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
学科主题生物基化学品
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]ENGINEERED ESCHERICHIA-COLI ; BACILLUS-MEGATERIUM ; LACTOCOCCUS-LACTIS ; XYLOSE UTILIZATION ; OUTER MEMBRANES ; YEAST-CELLS ; FATTY-ACIDS ; LAMBDA-S ; PCC 6803 ; EXPRESSION
收录类别SCI
语种英语
WOS记录号WOS:000322408100005
公开日期2014-03-21
源URL[http://ir.qibebt.ac.cn:8080/handle/337004/1660]  
专题青岛生物能源与过程研究所_材料生物技术研究中心
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Key Lab Biobased Mat, Qingdao 266101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Yongqiang,Feng, Xinjun,Xian, Mo,et al. Inducible cell lysis systems in microbial production of bio-based chemicals[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2013,97(16):7121-7129.
APA Gao, Yongqiang,Feng, Xinjun,Xian, Mo,Wang, Qi,&Zhao, Guang.(2013).Inducible cell lysis systems in microbial production of bio-based chemicals.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(16),7121-7129.
MLA Gao, Yongqiang,et al."Inducible cell lysis systems in microbial production of bio-based chemicals".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 97.16(2013):7121-7129.

入库方式： OAI收割

来源：青岛生物能源与过程研究所

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