LAMOST is a quasi-meridian reflecting Schmidt telescope, which consists of a reflecting Schmidt corrector MA, aspherical primary mirror MB and a focal plane. The telescope with its optical axis tilted by an angle of 25° to the horizon tracks the celestial objects by the movements of MA to make the light throughout aim at MB, and MB mirror consists of 37 spherical segments hanged upside down on the truss which tilted by about 25° to the horizon. This paper presents a design of MB sub-mirror segment handling manipulator for LAMOST, carries out a simulation analysis, presents an engineering program and describes the program's design principles and ideas. The manipulator including grab, declutch, elevation, stretch, pitching, rotation, automatic control and several other parts, and the control system can coordinate all these movements so that each segment can be located installed and handled precisely. In the structural design process the stiffness and positioning accuracy problems have been taken full account of.