Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia
文献类型：期刊论文
| 作者 | He, Kang1,2; Ma, Yun-Bao1; Cao, Tuan-Wu1,2; Wang, Hong-Ling1,2; Jiang, Fu-Qiang1; Geng, Chang-An1 ; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| 刊名 | PLANTA MEDICA
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| 出版日期 | 2012-05-01 |
| 卷号 | 78期号:8页码:814-820 |
| 关键词 | secoiridoids swertianglide swertianosides A-F Swertia angustifolia Gentianaceae anti-HBV activity |
| ISSN号 | 0032-0943 |
| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Kunming 650201, Peoples R China,chenjj@mail.kib.ac.cn |
| 英文摘要 | Seven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([alpha](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC50 0.18 mM, SI 3.11) and HBeAg (IC50 0.12 mM, SI 4.67). |
| 学科主题 | Plant Sciences ; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | CHEMICAL-CONSTITUENTS ; BUCH-HAM ; MILEENSIS ; GENTIANACEAE ; GLUCOSIDES ; XANTHONES ; GLYCOSIDE |
| 收录类别 | SCI |
| 资助信息 | We are thankful for the financial support from the National Natural Sciences Foundation of China for Distinguished Young Scholars (No. 81025023), National Natural Science Foundation of China and Yunan Province (Grant No. U0832603), and Major Project of Innovative Engineering (KSCX2-YW-R-181), and are also grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000304449300012 |
| 公开日期 | 2014-04-02 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17623]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Kang,Ma, Yun-Bao,Cao, Tuan-Wu,et al. Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia[J]. PLANTA MEDICA,2012,78(8):814-820. |
| APA | He, Kang.,Ma, Yun-Bao.,Cao, Tuan-Wu.,Wang, Hong-Ling.,Jiang, Fu-Qiang.,...&Chen, Ji-Jun.(2012).Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia.PLANTA MEDICA,78(8),814-820. |
| MLA | He, Kang,et al."Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia".PLANTA MEDICA 78.8(2012):814-820. |
入库方式： OAI收割
来源：昆明植物研究所
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