Chemical constituents from Aphanamixis grandifolia
文献类型：期刊论文
| 作者 | Zhang, Rong1,2; He, Hong-Ping1; Di, Ying-Tong1 ; Li, Shun-Lin1; Zuo, Guo-Ying3; Zhang, Yu1; Hao, Xiao-Jiang1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014 |
| 卷号 | 92页码:100-104 |
| 关键词 | Aphanamixis grandifolia Diterpenoid TDDFT Nemoralisins D-G |
| ISSN号 | 0367-326X |
| 通讯作者 | Zhang,Y (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Yunnan,Peoples R China. ; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn |
| 英文摘要 | Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with delta-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic diterpenoids, which are structurally related nemoralisin C and nemoralisin. These structures were established on the basis of spectroscopic methods and the absolute configuration of 1 was determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Nemoralisins D-G (1-4) were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines (IC50 > 40 mu M), as well as the antimicrobial activities on Staphylococcus aureus, Pseudomonas aeruginosa, MRSA92(#) and MRSA98(#) (MIC > 50 mu g/mL). (C) 2013 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | STEM BARKS ; CARBON SKELETON ; TRITERPENOIDS ; POLYSTACHYA ; LIMONOIDS ; DITERPENES |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China [2009CB522303] |
| 语种 | 英语 |
| WOS记录号 | WOS:000331420300013 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17925]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rong,He, Hong-Ping,Di, Ying-Tong,et al. Chemical constituents from Aphanamixis grandifolia[J]. FITOTERAPIA,2014,92:100-104. |
| APA | Zhang, Rong.,He, Hong-Ping.,Di, Ying-Tong.,Li, Shun-Lin.,Zuo, Guo-Ying.,...&Hao, Xiao-Jiang.(2014).Chemical constituents from Aphanamixis grandifolia.FITOTERAPIA,92,100-104. |
| MLA | Zhang, Rong,et al."Chemical constituents from Aphanamixis grandifolia".FITOTERAPIA 92(2014):100-104. |
入库方式： OAI收割
来源：昆明植物研究所
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