Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
文献类型：期刊论文
| 作者 | Fu, Yan-hui1,2 ; Di, Ying-tong1; He, Hong-ping1; Li, Shun-lin1; Zhang, Yu1; Hao, Xiao-jiang1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2014 |
| 卷号 | 77期号:1页码:57-62 |
| 关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY NATURALLY-OCCURRING SUBSTANCES ASPIDOSPERMANE-TYPE ALKALOIDS CATHARANTHUS-ROSEUS MELODINUS-SUAVEOLENS HUNTERIA-EBURNEA INDOLE ALKALOIDS VINCA ALKALOIDS NEW-CALEDONIA PLANTS |
| ISSN号 | 0163-3864 |
| 通讯作者 | Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn |
| 英文摘要 | Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures and absolute configurations were elucidated by a combination of MS, NMR, and computational methods. Angustifonines A and B exhibited cytotoxicity against various human cancer cell lines with IC50 values of 2.71-16.22 mu M. A possible biosynthesis pathway toward the new bisindole alkaloids 1 and 2 is presented. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | MAGNETIC-RESONANCE-SPECTROSCOPY ; NATURALLY-OCCURRING SUBSTANCES ; ASPIDOSPERMANE-TYPE ALKALOIDS ; CATHARANTHUS-ROSEUS ; MELODINUS-SUAVEOLENS ; HUNTERIA-EBURNEA ; INDOLE ALKALOIDS ; VINCA ALKALOIDS ; NEW-CALEDONIA ; PLANTS |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China [31100259]; National Basic Research Program of China [2009CB522303] |
| 语种 | 英语 |
| WOS记录号 | WOS:000330336800010 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17926]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,et al. Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):57-62. |
| APA | Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,Li, Shun-lin,Zhang, Yu,&Hao, Xiao-jiang.(2014).Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia.JOURNAL OF NATURAL PRODUCTS,77(1),57-62. |
| MLA | Fu, Yan-hui,et al."Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia".JOURNAL OF NATURAL PRODUCTS 77.1(2014):57-62. |
入库方式： OAI收割
来源：昆明植物研究所
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