Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera
文献类型：期刊论文
| 作者 | Liang, Cheng-Qin1,2,3; Luo, Rong-Hua4; Yan, Ju-Ming1; Li, Yan1 ; Li, Xiao-Nian1; Shi, Yi-Ming1,3; Shang, Shan-Zhai1,3; Gao, Zhong-Hua1,3; Yang, Liu-Meng4; Zheng, Yong-Tang4
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
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| 出版日期 | 2014-02-01 |
| 卷号 | 37期号:2页码:168-174 |
| ISSN号 | 0253-6269 |
| 关键词 | Schisandra sphenanthera Triterpenoid Cytotoxicity Anti-HIV-1 |
| 通讯作者 | Xiao,WL (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West,Kunming 650201,Peoples R China. ; xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 英文摘要 | Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 mu g ml(-1) and therapeutic index value of 117.12. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | ANTI-HIV ACTIVITY ; KADSURA INTERIOR ; UNIQUE SKELETON ; LIGNANS ; LANCIFOLIA ; NORTRITERPENOIDS ; LACTONES ; ACID |
| 资助信息 | Chinese Academy of Sciences [KSCX2-EW-Q-10]; NSFC [81102483, 81001462, 30830115]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]; Key Scientific and Technological Program of China [2012ZX10001-006]; project of recruited top talent of sciences and technology of Yunnan Province [2009C1120]; Natural Science Foundation of Yunnan Province [2012FB178] |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330958500002 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17929]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650201, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Cheng-Qin,Luo, Rong-Hua,Yan, Ju-Ming,et al. Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera[J]. ARCHIVES OF PHARMACAL RESEARCH,2014,37(2):168-174. |
| APA | Liang, Cheng-Qin.,Luo, Rong-Hua.,Yan, Ju-Ming.,Li, Yan.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2014).Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera.ARCHIVES OF PHARMACAL RESEARCH,37(2),168-174. |
| MLA | Liang, Cheng-Qin,et al."Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera".ARCHIVES OF PHARMACAL RESEARCH 37.2(2014):168-174. |
入库方式： OAI收割
来源：昆明植物研究所
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