Nortriterpenoids from Schisandra chinensis and their absolute configurational assignments by electronic circular dichroism study
文献类型：期刊论文
| 作者 | Shi, Yi-Ming1,3 ; Wang, Li-Yan2; Zou, Xi-Sheng1; Li, Xiao-Nian1; Shang, Shan-Zhai1,3; Gao, Zhong-Hua1,3; Liang, Cheng-Qin1,3; Luo, Huai-Rong1; Li, Hong-Lin2; Xiao, Wei-Lie1
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-01-28 |
| 卷号 | 70期号:4页码:859-868 |
| 关键词 | Schisandra Schisandra chinensis Nortriterpenoid Electronic circular dichroism Absolute configuration |
| ISSN号 | 0040-4020 |
| 通讯作者 | Xiao,WL (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 英文摘要 | Twelve new nortriterpenoids, namely wuweizidilactones J-P (1-7), schindilactones I-K (8-10), preschisanartanin N (11), and schisdilactone J (12), as well as 23 known analogues, were isolated from the leaves and stems of Schisandra chinensis. The absolute configurations of 1 and 11 were established by calculated electronic circular dichroism (ECD) spectra and that of 7 was confirmed by single-crystal X-ray diffraction. The absolute configurations of 2-6, 8, and 9 were determined by an empirical comparison of their experimental ECD spectra with that of 1. It is the first time that the ECD spectra of 18(13 -> 14)-abeoschiartane-, 18-norschiartane-, and schisanartane-type nortriterpenoids possessing an alpha,beta-unsaturated-gamma-lactone moiety are presented, this method providing an alternative means of obtaining absolute configurational assignments for these types of nortriterpenoids. All isolates were evaluated for their anti-acetylcholinesterase and anti-butyrylcholinesterase activities, and compounds 8, 13, 23, and 31 show anti-acetylcholinesterase activity at concentrations of 50 mu M, with 12.7, 10.7, 16.6, and 32.1% inhibition, respectively. (C) 2013 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | HIGHLY OXYGENATED NORTRITERPENOIDS ; PROPINQUA VAR. PROPINQUA ; ANTI-HIV ACTIVITY ; UNIQUE SKELETON ; LANCIFOLIA ; ARISANENSIS ; FRUITS ; SPHENANTHERA ; MICRANTHA |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China [81373290]; 973 program [2009CB522300]; NSF of Yunnan Province [2012FB178]; CAS grant [KSCX2-EW-Q-10]; SRF for ROCS, SEM; HPC Center of Kunming Institute of Botany, CAS |
| 语种 | 英语 |
| WOS记录号 | WOS:000330143800012 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17930]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Yi-Ming,Wang, Li-Yan,Zou, Xi-Sheng,et al. Nortriterpenoids from Schisandra chinensis and their absolute configurational assignments by electronic circular dichroism study[J]. TETRAHEDRON,2014,70(4):859-868. |
| APA | Shi, Yi-Ming.,Wang, Li-Yan.,Zou, Xi-Sheng.,Li, Xiao-Nian.,Shang, Shan-Zhai.,...&Sun, Han-Dong.(2014).Nortriterpenoids from Schisandra chinensis and their absolute configurational assignments by electronic circular dichroism study.TETRAHEDRON,70(4),859-868. |
| MLA | Shi, Yi-Ming,et al."Nortriterpenoids from Schisandra chinensis and their absolute configurational assignments by electronic circular dichroism study".TETRAHEDRON 70.4(2014):859-868. |
入库方式： OAI收割
来源：昆明植物研究所
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