Palladium-Catalyzed Unactivated C(sp(3))-H Bond Activation and intramolecular Amination of Carboxamides: A New Approach to beta-Lactams
文献类型：期刊论文
| 作者 | Sun, Wen-Wu1,2 ; Cao, Pei1; Mei, Ren-Qiang1; Li, Yue1; Ma, Yuan-Liang1; Wu, Bin1
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-01-17 |
| 卷号 | 16期号:2页码:480-483 |
| 关键词 | C-H ACTIVATION CARBON-HYDROGEN BONDS SIDE-CHAIN SAR ACID DERIVATIVES DIRECTING GROUP ARYLATION FUNCTIONALIZATION INHIBITORS GAMMA CONSTRUCTION |
| ISSN号 | 1523-7060 |
| 通讯作者 | Wu,B (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; wubin@mail.kib.ac.cn |
| 英文摘要 | An efficient method to synthesize the beta-lactams with high regioselectivity via Pd-catalyzed C(sp(3))-H bond activation and intramolecular arnination of simple and readily available aminoquinoline carboxamides was demonstrated. C6F5I plays a significant role in the formation of the C-N bond of the four-membered ring beta-lactams. High yield along with wide substrate scope and functional group tolerance makes this reaction applicable to build natural-product-derived beta-lactams. This method has been applied to the efficient synthesis of the beta-lactamase inhibitor MK-8712. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | C-H ACTIVATION ; CARBON-HYDROGEN BONDS ; SIDE-CHAIN SAR ; ACID DERIVATIVES ; DIRECTING GROUP ; ARYLATION ; FUNCTIONALIZATION ; INHIBITORS ; GAMMA ; CONSTRUCTION |
| 收录类别 | SCI ; IC ; CCR |
| 资助信息 | Hundred Talents Project of Chinese Academy of Science; "High-end Science and Technology Talents Program" of Yunnan Province [2011HA008] |
| 语种 | 英语 |
| WOS记录号 | WOS:000330098400040 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17931]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Wen-Wu,Cao, Pei,Mei, Ren-Qiang,et al. Palladium-Catalyzed Unactivated C(sp(3))-H Bond Activation and intramolecular Amination of Carboxamides: A New Approach to beta-Lactams[J]. ORGANIC LETTERS,2014,16(2):480-483. |
| APA | Sun, Wen-Wu,Cao, Pei,Mei, Ren-Qiang,Li, Yue,Ma, Yuan-Liang,&Wu, Bin.(2014).Palladium-Catalyzed Unactivated C(sp(3))-H Bond Activation and intramolecular Amination of Carboxamides: A New Approach to beta-Lactams.ORGANIC LETTERS,16(2),480-483. |
| MLA | Sun, Wen-Wu,et al."Palladium-Catalyzed Unactivated C(sp(3))-H Bond Activation and intramolecular Amination of Carboxamides: A New Approach to beta-Lactams".ORGANIC LETTERS 16.2(2014):480-483. |
入库方式： OAI收割
来源：昆明植物研究所
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