Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines
文献类型：期刊论文
| 作者 | Bai, Bing1,2; Li, Xing-Yao3; Liu, Li1 ; Li, Yan3; Zhu, Hua-Jie1,3
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:1页码:96-98 |
| ISSN号 | 0960-894X |
| 关键词 | beta-Carbolines Cytotoxic activity Structure-activity relationship MTT |
| 通讯作者 | Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; hjzhu@mail.kib.ac.cn |
| 英文摘要 | A series of beta-carbolines possessing the aryl group at C-1 position has been synthesized from tryptophan. The newly synthesized compounds were screened for their in vitro anticancer activity against various human cancer cell lines by MTT assay. Some of them exhibited anticancer activity with IC50 values lower than 10 mu M outdistanced the cisplatin level. Structure-activity relationship reveals that the alcohol substituents at C-3 position played an important role in inhibition activity. (C) 2013 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | ALKALOIDS ; INHIBITORS |
| 资助信息 | Hebei University; Yunnan Province [2009CI120] |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000329114200014 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17939]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Hebei Univ, Dept Chem & Chem Engn, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diagnost, Baoding 071002, Peoples R China 2.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou 450002, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Bing,Li, Xing-Yao,Liu, Li,et al. Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(1):96-98. |
| APA | Bai, Bing,Li, Xing-Yao,Liu, Li,Li, Yan,&Zhu, Hua-Jie.(2014).Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(1),96-98. |
| MLA | Bai, Bing,et al."Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.1(2014):96-98. |
入库方式： OAI收割
来源：昆明植物研究所
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