(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3
文献类型：期刊论文
| 作者 | Yan, Yong-Ming1,4; Ai, Jun3; Shi, Yan-Ni1,4; Zuo, Zhi-Li1 ; Hou, Bo1; Luo, Jie1; Cheng, Yong-Xian1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-01-17 |
| 卷号 | 16期号:2页码:532-535 |
| 关键词 | DISEASE PRODUCTS |
| ISSN号 | 1523-7060 |
| 通讯作者 | Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,132 Lanhei Rd,Kunming 650201,Peoples R China. ; yxcheng@mail.kib.ac.cn |
| 英文摘要 | (+/-)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-beta 1 (TGF-beta 1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions. |
| 学科主题 | Chemistry, Organic |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | DISEASE ; PRODUCTS |
| 收录类别 | SCI ; IC |
| 资助信息 | National Natural Science Foundation of China [21272241, 21172223]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources |
| 语种 | 英语 |
| WOS记录号 | WOS:000330098400053 |
| 公开日期 | 2014-04-09 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17944]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Yong-Ming,Ai, Jun,Shi, Yan-Ni,et al. (+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3[J]. ORGANIC LETTERS,2014,16(2):532-535. |
| APA | Yan, Yong-Ming.,Ai, Jun.,Shi, Yan-Ni.,Zuo, Zhi-Li.,Hou, Bo.,...&Cheng, Yong-Xian.(2014).(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3.ORGANIC LETTERS,16(2),532-535. |
| MLA | Yan, Yong-Ming,et al."(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3".ORGANIC LETTERS 16.2(2014):532-535. |
入库方式： OAI收割
来源：昆明植物研究所
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