Fabrication of a Detection Platform with Boronic-Acid-Containing Zwitterionic Polymer Brush
文献类型：期刊论文
| 作者 | Song LJ ; Zhao J ; Luan SF ; Ma J ; Liu JC ; Xu XD ; Yin JH |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:24页码:13207-13215 |
| 关键词 | ANTI-FOULING SURFACES ORIENTED IMMOBILIZATION PROTEIN ADSORPTION 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE COVALENT IMMOBILIZATION BIOLOGICAL APPLICATIONS SUPPORT SURFACES PHYSIOLOGICAL PH ACTIVE PROTEINS BLOOD-PLASMA |
| ISSN号 | 1944-8244 |
| 通讯作者 | luan sf |
| 中文摘要 | development of technologies for biomedical detection platform is critical to meet the global challenges of various disease diagnoses, especially for point-of-use applications. because of its natural simplicity, effectiveness, and easy repeatability, random covalent-binding technique is widely adopted in antibody immobilization. however, its antigen-binding capacity is relatively low when compared to site-specific immobilization of antibody. herein, we report that a detection platform modified with boronic acid (ba)-containing sulfobetaine-based polymer brush. mainly because of the advantage of oriented immobilization of antibody endowed with ba-containing three-dimensional polymer brush architecture, the platform had a high antigen-binding capacity. notably, nonspecific protein adsorption was also suppressed by the zwitterionic pendants, thus greatly enhanced signal-to-noise (s/n) values for antigen recognition. furthermore, antibodies captured by ba pendants could be released in dissociation media. this new platform is promising for potential applications in immunoassays. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000329137400059 |
| 公开日期 | 2014-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49379]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song LJ,Zhao J,Luan SF,et al. Fabrication of a Detection Platform with Boronic-Acid-Containing Zwitterionic Polymer Brush[J]. acs applied materials & interfaces,2013,5(24):13207-13215. |
| APA | Song LJ.,Zhao J.,Luan SF.,Ma J.,Liu JC.,...&Yin JH.(2013).Fabrication of a Detection Platform with Boronic-Acid-Containing Zwitterionic Polymer Brush.acs applied materials & interfaces,5(24),13207-13215. |
| MLA | Song LJ,et al."Fabrication of a Detection Platform with Boronic-Acid-Containing Zwitterionic Polymer Brush".acs applied materials & interfaces 5.24(2013):13207-13215. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。