Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site
文献类型：期刊论文
| 作者 | Zhao CQ ; Wu L ; Ren JS ; Xu Y ; Qu XG |
| 刊名 | journal of the american chemical society
 |
| 出版日期 | 2013 |
| 卷号 | 135期号:50页码:18786-18789 |
| 关键词 | INTRAMOLECULAR G-QUADRUPLEX K+ SOLUTION HUMAN-CELLS SEQUENCE STABILITY COMPLEXES NA+ MULTIMERS INSIGHTS LIGANDS |
| ISSN号 | 0002-7863 |
| 通讯作者 | qu xg |
| 中文摘要 | long human telomeric fragments can form stable, higher-order g-quadruplex structures, recently identified in human cells, which are potential drug targets. however, there are very few examples of ligand binding to higher-order g-quadruplexes, and all the reported ligands are proposed to bind at the cleft between two g-quadruplexes. here we report that zinc-finger-like chiral supramolecular complexes prefer binding to higher-order g-quadruplexes over a single g-quadruplex, with similar to 200-fold higher selectivity. to our knowledge, this is the first example of a ligand that can distinguish higher-order g-quadruplexes from a single g-quadruplex with such high selectivity. further studies indicate that the nanosized chiral complex would bind to two well-matched g-quadruplex units, instead of binding at the cleft between the two g-quadruplexes. these results provide new insights into the targeting of higher-order g-quadruplex ligands. our work illustrates that dimeric g-quadruplex units can be ligand-preferred binding sites. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000328865100021 |
| 公开日期 | 2014-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49386]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao CQ,Wu L,Ren JS,et al. Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site[J]. journal of the american chemical society,2013,135(50):18786-18789. |
| APA | Zhao CQ,Wu L,Ren JS,Xu Y,&Qu XG.(2013).Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site.journal of the american chemical society,135(50),18786-18789. |
| MLA | Zhao CQ,et al."Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site".journal of the american chemical society 135.50(2013):18786-18789. |
入库方式： OAI收割
来源：长春应用化学研究所
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