Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery
文献类型：期刊论文
| 作者 | Ding JX ; Xu WG ; Zhang Y ; Sun DK ; Xiao CS ; Liu DH ; Zhu XJ ; Chen XS |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2013 |
| 卷号 | 172期号:2页码:444-455 |
| 关键词 | MACROMOLECULAR THERAPEUTICS POLY(L-GLUTAMIC ACID) CANCER-TREATMENT IN-VITRO PH RELEASE NANOPARTICLES CHEMOTHERAPY MICELLES TRANSFECTION |
| ISSN号 | 0168-3659 |
| 通讯作者 | xiao cs |
| 中文摘要 | the ph and reduction dual-responsive polypeptide nanogels with self-reinforced endocytoses were prepared through ring-opening polymerization of l-glutamate n-carboxyanhydrides, deprotection of benzyl group and subsequent quaternization reaction between. gamma-2-chloroethyl-l-glutamate unit in polypeptide block and 2,2'-dithiobis(n, n-dimethylethylamine). the nanogels were revealed to exhibit smart ph and reduction dual-responsiveness, and excellent biocompatibilities, which expressed great potential as antitumor drug nanocarriers. doxorubicin (dox) as a model antitumor drug was loaded into nanogels through dispersion. dox-loaded nanogels displayed a stable core-cross-linked structure under normal physiological condition (ph 7.4), while rapidly releasing the payloads in the mimicking endosomal (ph 5.3), tumor tissular (ph 6.8) or intracellular reductive microenvironments (10.0 mm glutathione). confocal fluorescence microscopy demonstrated that dox-loaded nanogels could deliver dox into hepg2 cells (a human hepatoma cell line) more efficiently than the parent dox- loaded micelle and free dox. the enhanced cellular internalizations of dox- loaded nanogels were more significant under tumor tissular acidic condition (ph 6.8) ascribed to the quaternary ammonium groups in the cores. in addition, dox- loaded nanogels exhibited improved in vitro and in vivo antitumor activities, and in vivo securities compared with dox- loaded micelle and free dox. these excellent features of the smart nanogels with quaternary ammonium groups were endowed with a bright prospect for intracellular targeting antitumor drug delivery. (c) 2013 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327601700008 |
| 公开日期 | 2014-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49404]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,Xu WG,Zhang Y,et al. Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery[J]. journal of controlled release,2013,172(2):444-455. |
| APA | Ding JX.,Xu WG.,Zhang Y.,Sun DK.,Xiao CS.,...&Chen XS.(2013).Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery.journal of controlled release,172(2),444-455. |
| MLA | Ding JX,et al."Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery".journal of controlled release 172.2(2013):444-455. |
入库方式： OAI收割
来源：长春应用化学研究所
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