Dehydrogenation and dehalogenation of amines in MALDI-TOF MS investigated by isotopic labeling
文献类型：期刊论文
| 作者 | Kang CQ ; Zhou YH ; Du ZJ ; Bian Z ; Wang JW ; Qiu XP ; Gao LX ; Sun YQ |
| 刊名 | journal of mass spectrometry
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:12页码:1318-1324 |
| 关键词 | DESORPTION/IONIZATION MASS-SPECTROMETRY C BOND FORMATION VISIBLE-LIGHT OXIDATION DECHLORINATION IONIZATION CATALYSIS RADICALS |
| ISSN号 | 1076-5174 |
| 通讯作者 | kang cq |
| 中文摘要 | secondary and tertiary amines have been reported to form [m-h](+) that correspond to dehydrogenation in matrix-assisted laser desorption ionization time of flight mass spectrometry (maldi-tof ms). in this investigation, we studied the dehydrogenation of amines in maldi-tof ms by isotopic labeling. aliphatic amines were labeled with deuterium on the methylene of an n-benzyl group, which resulted in the formation of [m-d](+) and [m-h](+) ions by dedeuteration and dehydrogenation, respectively. this method revealed the proton that was removed. the spectra of most tertiary amines with an n-benzyl group showed high-intensity [m-d](+) and [m-h](+) ion peaks, whereas those of secondary amines showed low-intensity ion peaks. ratios between the peak intensities of [m-d](+) and [m-h](+) greater than 1 suggested chemoselective dehydrogenation at the n-benzyl groups. the presence of an electron donor group on the n-benzyl groups enhanced the selectivity. the dehalogenation of amines with an n-(4-halobenzyl) group was also observed alongside dehydrogenation. the amino ions from dehalogenation can undergo second dehydrogenation. these results provide the first direct evidence about the position at which dehydrogenation of an amine occurs and the first example of dehalogenation of haloaromatic compounds in maldi-tof ms. these results should be helpful in the structural identification and elucidation of synthetic and natural molecules. copyright (c) 2013 john wiley & sons, ltd. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000328252800010 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49428]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang CQ,Zhou YH,Du ZJ,et al. Dehydrogenation and dehalogenation of amines in MALDI-TOF MS investigated by isotopic labeling[J]. journal of mass spectrometry,2013,48(12):1318-1324. |
| APA | Kang CQ.,Zhou YH.,Du ZJ.,Bian Z.,Wang JW.,...&Sun YQ.(2013).Dehydrogenation and dehalogenation of amines in MALDI-TOF MS investigated by isotopic labeling.journal of mass spectrometry,48(12),1318-1324. |
| MLA | Kang CQ,et al."Dehydrogenation and dehalogenation of amines in MALDI-TOF MS investigated by isotopic labeling".journal of mass spectrometry 48.12(2013):1318-1324. |
入库方式： OAI收割
来源：长春应用化学研究所
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