Cationic Dendron-Bearing Lipids: Investigating Structure-Activity Relationships for Small Interfering RNA Delivery
文献类型：期刊论文
| 作者 | Zhang Y ; Chen J ; Xiao CS ; Li MQ ; Tian HY ; Chen XS |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2013 |
| 卷号 | 14期号:12页码:4289-4300 |
| 关键词 | GENE DELIVERY SIRNA DELIVERY DRUG-DELIVERY IN-VITRO TRANSFECTION ACTIVITY PAMAM DENDRIMERS BLOCK-COPOLYMERS CLICK CHEMISTRY NANOPARTICLES CANCER |
| ISSN号 | 1525-7797 |
| 通讯作者 | chen xs |
| 中文摘要 | a new family of cationic dendron-bearing lipids (cdls) with poly(amidoamine) dendrons of first to third generation (named as al, a2, and a3, respectively) was synthesized through a synthesis approach that permits facile variation of chemical structures. all cdls could effectively complexes exhibited significant gene silencing efficiency close to lipofectamine 2000/sirna complexes and much higher than a2/sirna and a3/ sirna complexes. to reveal the underlying reason, we performed series of experimental methods. the results suggested that the cdls with smaller dendron sizes and higher proportion of hydrophobic segments could bind sirna to form dendriplex aggregates with more compact structures and higher surface potentials. therefore, they could be internalized via endocytosis more easily, which was believed to be the main reason for higher gene silencing efficiency. this paper provides an efficient cdl (al) for sirna delivery and indicates great potential for gene therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000328240400015 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49430]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang Y,Chen J,Xiao CS,et al. Cationic Dendron-Bearing Lipids: Investigating Structure-Activity Relationships for Small Interfering RNA Delivery[J]. biomacromolecules,2013,14(12):4289-4300. |
| APA | Zhang Y,Chen J,Xiao CS,Li MQ,Tian HY,&Chen XS.(2013).Cationic Dendron-Bearing Lipids: Investigating Structure-Activity Relationships for Small Interfering RNA Delivery.biomacromolecules,14(12),4289-4300. |
| MLA | Zhang Y,et al."Cationic Dendron-Bearing Lipids: Investigating Structure-Activity Relationships for Small Interfering RNA Delivery".biomacromolecules 14.12(2013):4289-4300. |
入库方式： OAI收割
来源：长春应用化学研究所
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