Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs
文献类型：期刊论文
| 作者 | Cheng YL ; He CL ; Ding JX ; Xiao CS ; Zhuang XL ; Chen XS |
| 刊名 | biomaterials
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:38页码:10338-10347 |
| 关键词 | CONTROLLED-RELEASE BLOCK-COPOLYMERS BIODEGRADABLE POLYMERS AQUEOUS-SOLUTION IN-VIVO PACLITAXEL GELATION SOL GEL COMBINATION |
| ISSN号 | 0142-9612 |
| 通讯作者 | chen xs |
| 中文摘要 | thermosensitive hydrogels based on poly(gamma-ethyl-l-glutamate)-poly(ethylene glycol)-poly(gamma-ethyl-l-glutamate) triblock copolymers (pelg-peg-pelg) were prepared for localized and sustained delivery of anticancer drugs. the polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional polyester-based hydrogels. in vivo biocompatibility studies revealed that the in situ formed gels in the subcutaneous layer last for similar to 21 days, and h&e staining study suggested acceptable biocompatibility of our materials in vivo. then the hydrogels were tried as injectable implants to encapsulate antitumor drug, paclitaxel (ptx), to assess the in situ anti-tumoral activity using liver cancer xenograft model. the results demonstrated that the ptx-incorporated hydrogels could efficiently suppress the tumor growth, and did not result in obvious damage to normal organs. therefore, the polypeptide-based thermosensitive hydrogels designed in the present study have great potential to serve as an effective platform for localized anti-cancer drug delivery. (c) 2013 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000328094600059 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49431]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cheng YL,He CL,Ding JX,et al. Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs[J]. biomaterials,2013,34(38):10338-10347. |
| APA | Cheng YL,He CL,Ding JX,Xiao CS,Zhuang XL,&Chen XS.(2013).Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs.biomaterials,34(38),10338-10347. |
| MLA | Cheng YL,et al."Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs".biomaterials 34.38(2013):10338-10347. |
入库方式： OAI收割
来源：长春应用化学研究所
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