Gold Nanocage-Based Dual Responsive "Caged Metal Chelator" Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease
文献类型：期刊论文
| 作者 | Shi P ; Li M ; Ren JS ; Qu XG |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:43页码:5412-5419 |
| 关键词 | AMYLOID-BETA-PEPTIDE BLOOD-BRAIN-BARRIER A-BETA MESOPOROUS SILICA DRUG-DELIVERY CANCER-CELLS HYDROGEN-PEROXIDE PHOTOTHERMAL DESTRUCTION OPTICAL-PROPERTIES AGGREGATION |
| ISSN号 | 1616-301x |
| 通讯作者 | shi p |
| 中文摘要 | metal ions have been demonstrated to participate in the pathology of alzheimer's disease (ad): amyloid- peptide (a) aggregation and formation of neurotoxic reactive oxygen species (ros), such as h2o2. metal chelator can block ros formation and inhibit metal induced a aggregation. metal-ion chelation therapy as a compelling treatment for ad has been extensively studied. however, most chelators are not suitable for ad treatment because of their poor permeability of the blood-brain barrier and their limited ability to differentiate toxic metals associated with a plaques from those associated with normal metal homeostasis. here, a novel dual-responsive caged metal chelator release system based on gold nanocage (aunc) for ad treatment is reported. since arylboronic ester is redox- and thermal-sensitive, phenylboronic acid-functionalized aunc can serve as an efficient delivery system for h2o2-responsive controlled release of metal chelator. the release can be further enhanced through remote control with nir light because of the high near-infrared absorbance of aunc. the smart system can effectively inhibit a aggregate formation, decrease cellular ros, and protect cells from a-related toxicity. in light of these advantages, this design provides new insights into noninvasive remote control with nir to improve therapeutic efficacy for treatment of alzheimer's disease. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327472900012 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49455]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Shi P,Li M,Ren JS,et al. Gold Nanocage-Based Dual Responsive "Caged Metal Chelator" Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease[J]. advanced functional materials,2013,23(43):5412-5419. |
| APA | Shi P,Li M,Ren JS,&Qu XG.(2013).Gold Nanocage-Based Dual Responsive "Caged Metal Chelator" Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease.advanced functional materials,23(43),5412-5419. |
| MLA | Shi P,et al."Gold Nanocage-Based Dual Responsive "Caged Metal Chelator" Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease".advanced functional materials 23.43(2013):5412-5419. |
入库方式： OAI收割
来源：长春应用化学研究所
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