Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms
文献类型：期刊论文
| 作者 | Zhang Z ; Chen XF ; Chen L ; Yu SJ ; Cao Y ; He CL ; Chen XS |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:21页码:10760-10766 |
| 关键词 | GENE DELIVERY MULTIFUNCTIONAL NANOPARTICLES POLYMERIC CARRIERS RELEASE CANCER COPOLYMER MICELLES SYSTEMS DESIGN PARTICLES |
| ISSN号 | 1944-8244 |
| 通讯作者 | chen l |
| 中文摘要 | intracellular ph-sensitive micelles of peg-block-acetalated-dextran (peg-b-ac-dex) were prepared and used for acid-triggered intracellular release of anticancer drug. the hydrodynamic radii (r-h) of peg-b-ac-dex micelles could increase after incubation in pbs solution at ph 5.5. based on the ph-responsive r-h variation behavior, it was expected that the peg-b-ac-dex micelles should be interesting for intracellular drug delivery. thus, doxorubicin (dox), a wide-spectrum anticancer drug, was loaded into the micelles and the ph-dependent release of the payload dox was tested in vitro. the in vitro drug release profiles showed that only a small amount of the loaded dox was released in pbs solution at ph 7.4, while up to about 90% of the loaded dox could be quickly released in pbs solution at ph 5.5. compared to ph-insensitive peg-pla micelles, the peg-b-ac-dex micelles displayed a faster drug release behavior in tumor cells. moreover, higher cellular proliferation inhibition efficacy was achieved toward tumor cells. these features suggested that dox could be efficiently loaded and delivered into tumor cells in vitro by the intracelluar ph-sensitive micelles, leading to enhanced inhibition of tumor cell proliferation. therefore, the ph-sensitive micelles may provide a promising carrier for acid-triggered drug release for cancer therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327103500047 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49480]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang Z,Chen XF,Chen L,et al. Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms[J]. acs applied materials & interfaces,2013,5(21):10760-10766. |
| APA | Zhang Z.,Chen XF.,Chen L.,Yu SJ.,Cao Y.,...&Chen XS.(2013).Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms.acs applied materials & interfaces,5(21),10760-10766. |
| MLA | Zhang Z,et al."Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms".acs applied materials & interfaces 5.21(2013):10760-10766. |
入库方式： OAI收割
来源：长春应用化学研究所
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