Polymeric topology and composition constrained polyether-polyester micelles for directional antitumor drug delivery
文献类型：期刊论文
| 作者 | Li D ; Sun H ; Ding JX ; Tang ZH ; Zhang Y ; Xu WG ; Zhuang XL ; Chen XS |
| 刊名 | acta biomaterialia
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:11页码:8875-8884 |
| 关键词 | BLOCK-COPOLYMERS IN-VITRO BIODEGRADABLE POLYMER POLY(L-GLUTAMIC ACID) POLYPEPTIDE NANOGELS KINETIC STABILITY NANOPARTICLES DOXORUBICIN PH PACLITAXEL |
| ISSN号 | 1742-7061 |
| 通讯作者 | ding jx |
| 中文摘要 | amphiphilic linear and dumbbell-shaped poly(ethylene glycol)-poly(lactide-co-glycolide) (peg-plga) copolymers were simply synthesized by the ring-opening polymerization of lactide and glycolide using peg or tetrahydroxyl-functionalized peg as the macroinitiator and stannous octoate as the catalyst. the copolymers spontaneously self-assembled into spherical micelles in phosphate-buffered saline at ph 7.4. the self-assembly behavior was dependent on both the polymeric topology and composition. doxorubicin (dox), an anthracycline antitumor drug, was loaded into micelles through nanoprecipitation. the in vitro release behavior could be adjusted by regulating the topology or composition of the copolymer, or the ph of the release medium. the effective intracellular dox release from dox-loaded micelles was confirmed by confocal laser scanning microscopy and flow cytometry in vitro. dox-loaded micelles displayed great cellular proliferation inhibition efficacies after incubation for 24,48 or 72 h. the hemolysis ratio of dox was significantly reduced by the presence of copolymer. these properties indicated that the micelles derived from linear or dumbbell-shaped copolymers were promising candidates as smart antitumor drug carriers for malignancy therapy. (c) 2013 acta materialia inc. published by elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000326902500010 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49500]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li D,Sun H,Ding JX,et al. Polymeric topology and composition constrained polyether-polyester micelles for directional antitumor drug delivery[J]. acta biomaterialia,2013,9(11):8875-8884. |
| APA | Li D.,Sun H.,Ding JX.,Tang ZH.,Zhang Y.,...&Chen XS.(2013).Polymeric topology and composition constrained polyether-polyester micelles for directional antitumor drug delivery.acta biomaterialia,9(11),8875-8884. |
| MLA | Li D,et al."Polymeric topology and composition constrained polyether-polyester micelles for directional antitumor drug delivery".acta biomaterialia 9.11(2013):8875-8884. |
入库方式： OAI收割
来源：长春应用化学研究所
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