Biodegradable Stereocomplex Micelles Based on Dextran-block-polylactide as Efficient Drug Deliveries
文献类型：期刊论文
| 作者 | Zhao ZW ; Zhang Z ; Chen L ; Cao Y ; He CL ; Chen XS |
| 刊名 | langmuir
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:42页码:13072-13080 |
| 关键词 | MULTIFUNCTIONAL NANOPARTICLES ORGANOCATALYTIC APPROACH COPOLYMER MICELLES GRAFTED DEXTRAN RELEASE DEGRADATION STABILITY HYDROGELS PH |
| ISSN号 | 0743-7463 |
| 通讯作者 | chen l |
| 中文摘要 | biodegradable stereocomplex micelles (scms) based on amphiphilic dextran-block-polylactide (dex-b-pla) were designed and used for efficient intracellular drug deliveries. the dex-b-pla copolymers were successfully synthesized by click reaction. the structures of the resultant copolymers were verified by h-1 nmr and ft-ir spectra. the formation of stable micelles through self-assembly driven by the stereocomplexation between enantiomeric l- and d-pla blocks was characterized by transmission electron microscopy (tem), dynamic laser scattering (dls), and fluorescence techniques. it was interesting to observe that the scms showed lower critical micelle concentration values (cmcs) because of the stereocomplex interaction between plla and pdla. differential scanning calorimetry (dsc) and x-ray diffraction (xrd) analysis provided information on the thermal and crystal properties of the copolymers and scms. the improved stability of scms should be attractive for intracellular drug delivery. thus, a model anticancer drug doxorubicin (dox) was loaded into micelles, and the in vitro drug release in was also studied. the release kinetics of dox showed dox-loaded scms exhibited slower dox release. confocal laser scanning microscopy (clsm) and flow cytometry studies also showed that the dox-loaded scms exhibited a slower drug release behavior. meanwhile, the mtt assay demonstrated that dox-loaded scms show lower cellular proliferation inhibition against hepg2. in sum, the micelles through self-assembly driven by stereocomplex interaction would have great potential to be used as stable delivery vehicles for pharmaceutical and biomedical applications. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000326209500023 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49532]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao ZW,Zhang Z,Chen L,et al. Biodegradable Stereocomplex Micelles Based on Dextran-block-polylactide as Efficient Drug Deliveries[J]. langmuir,2013,29(42):13072-13080. |
| APA | Zhao ZW,Zhang Z,Chen L,Cao Y,He CL,&Chen XS.(2013).Biodegradable Stereocomplex Micelles Based on Dextran-block-polylactide as Efficient Drug Deliveries.langmuir,29(42),13072-13080. |
| MLA | Zhao ZW,et al."Biodegradable Stereocomplex Micelles Based on Dextran-block-polylactide as Efficient Drug Deliveries".langmuir 29.42(2013):13072-13080. |
入库方式： OAI收割
来源：长春应用化学研究所
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