Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine
文献类型：期刊论文
| 作者 | Chen J ; Tian HY ; Dong X ; Guo ZP ; Jiao ZX ; Li FF ; Kano A ; Maruyama A ; Chen XS |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2013 |
| 卷号 | 13期号:10页码:1438-1446 |
| 关键词 | ENDOTHELIAL GROWTH-FACTOR AMINO-ACID SEGMENT HYPERBRANCHED PEI GENE DELIVERY IN-VITRO MICELLES RNA CANCER PBLG NANOPARTICLES |
| ISSN号 | 1616-5187 |
| 通讯作者 | tian hy |
| 中文摘要 | two copolymers are designed and synthesised for sirna delivery based on polyethylenimine by grafting hydrophilic acrylamide segments and hydrophobic poly(gamma-benzyl l-glutamate). the amphiphilic pei-pblg/sirna complex demonstrates high gene silencing efficiency in the absence or presence of 10 vol% and 50 vol% sera in vitro. the anti-tumor effects in vivo are evaluated in luciferase-bearing mice expressing ct26 tumors. pei-pblg/sivegf complex provides a higher and more sustained suppressive effect by reducing vegf mrna expression in the tumors, leading to higher tumor growth inhibition efficacy. further studies on the potential use of the pei-pblg carrier system in mediating the silencing of genes other than vegf or in other tumor models are recommended. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000328744300018 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49555]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen J,Tian HY,Dong X,et al. Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine[J]. macromolecular bioscience,2013,13(10):1438-1446. |
| APA | Chen J.,Tian HY.,Dong X.,Guo ZP.,Jiao ZX.,...&Chen XS.(2013).Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine.macromolecular bioscience,13(10),1438-1446. |
| MLA | Chen J,et al."Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine".macromolecular bioscience 13.10(2013):1438-1446. |
入库方式： OAI收割
来源：长春应用化学研究所
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