Mutation induced structural variation in membrane proteins
文献类型：期刊论文
| 作者 | Duan XZ ; Li YQ ; Shi TF ; Huang QR ; An LJ |
| 刊名 | chemical research in chinese universities
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:5页码:1016-1021 |
| 关键词 | FUNCTIONAL DOMAIN COMPOSITION ATOM FORCE-FIELD STRUCTURE PREDICTION SECONDARY STRUCTURE STATISTICAL POTENTIALS STRUCTURE REFINEMENT MODELS STABILITY DISTANCE ALGORITHM |
| ISSN号 | 1005-9040 |
| 通讯作者 | shi tf |
| 中文摘要 | point mutations on membrane proteins may lead to small structural variations. prediction of such structural variations can help to further understand the related bio-activities of membrane proteins. we constructed fifteen hybrid energy functions on the basis of chemistry at harvard macromolecular mechanics(charmm) force field, hydrogen bonding potential and distance-scaled, finite ideal-gas reference(dfire)-like statistical energies, and evaluated their performance on a representative dataset of homologous membrane proteins via a newly developed all-atom replica exchange monte carlo algorithm. the energy function composed of charmm and hydrogen bonding potential has the best performance, and the original dfire potential shows much better performance than the dfire-like potentials constructed from membrane proteins. we can conclude that more membrane protein structures with high resolution are necessary for the construction of robust prediction method of mutation induced membrane protein structure variations. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000325359400037 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49570]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Duan XZ,Li YQ,Shi TF,et al. Mutation induced structural variation in membrane proteins[J]. chemical research in chinese universities,2013,29(5):1016-1021. |
| APA | Duan XZ,Li YQ,Shi TF,Huang QR,&An LJ.(2013).Mutation induced structural variation in membrane proteins.chemical research in chinese universities,29(5),1016-1021. |
| MLA | Duan XZ,et al."Mutation induced structural variation in membrane proteins".chemical research in chinese universities 29.5(2013):1016-1021. |
入库方式： OAI收割
来源：长春应用化学研究所
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