Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes
文献类型：期刊论文
| 作者 | Liu Z ; Ju EG ; Liu JH ; Du YD ; Li ZQ ; Yuan QH ; Ren JS ; Qu XG |
| 刊名 | biomaterials
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:30页码:7444-7452 |
| 关键词 | RAY COMPUTED-TOMOGRAPHY IN-VIVO BIODISTRIBUTION MESOPOROUS SILICA NANOPARTICLES BISMUTH SULFIDE NANOPARTICLES CONTRAST AGENTS HEMOLYTIC-ACTIVITY QUANTUM DOTS CT NANOCRYSTALS TOXICITY |
| ISSN号 | 0142-9612 |
| 通讯作者 | ren js |
| 中文摘要 | nanoparticulate contrast agents have attracted a great deal of attention along with the rapid development of modern medicine. here, a binary contrast agent based on paa modified baybf5:tm nanoparticles for direct visualization of gastrointestinal (gi) tract has been designed and developed via a one-pot solvothermal route. by taking advantages of excellent colloidal stability, low cytotoxicity, and neglectable hemolysis of these well-designed nanoparticles, their feasibility as a multi-modal contrast agent for gi tract was intensively investigated. significant enhancement of contrast efficacy relative to clinical barium meal and iodine-based contrast agent was evaluated via x-ray imaging and ct imaging in vivo. by doping tm3+ ions into these nanoprobes, in vivo nir-nir imaging was then demonstrated. unlike some invasive imaging modalities, non-invasive imaging strategy including x-ray imaging, ct imaging, and ucl imaging for gi tract could extremely reduce the painlessness to patients, effectively facilitate imaging procedure, as well as rationality economize diagnostic time. critical to clinical applications, long-term toxicity of our contrast agent was additionally investigated in detail, indicating their overall safety. based on our results, paa-baybf5:tm nanoparticles were the excellent multi-modal contrast agent to integrate x-ray imaging, ct imaging, and ucl imaging for direct visualization of gi tract with low systemic toxicity. (c) 2013 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322931900024 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49589]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu Z,Ju EG,Liu JH,et al. Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes[J]. biomaterials,2013,34(30):7444-7452. |
| APA | Liu Z.,Ju EG.,Liu JH.,Du YD.,Li ZQ.,...&Qu XG.(2013).Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes.biomaterials,34(30),7444-7452. |
| MLA | Liu Z,et al."Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes".biomaterials 34.30(2013):7444-7452. |
入库方式： OAI收割
来源：长春应用化学研究所
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