Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release
文献类型：期刊论文
| 作者 | Zhang X ; Yang PP ; Dai YL ; Ma PA ; Li XJ ; Cheng ZY ; Hou ZY ; Kang XJ ; Li CX ; Lin J |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:33页码:4067-4078 |
| 关键词 | VIVO PHOTODYNAMIC THERAPY DOPED NAYF4 NANOCRYSTALS BIOIMAGING IN-VIVO CONVERSION NANOPARTICLES SILICA NANOPARTICLES MAGNETIC-RESONANCE UPCONVERTING NANOPARTICLES BIOMEDICAL APPLICATIONS PHOTOTHERMAL THERAPY QUANTUM DOTS |
| ISSN号 | 1616-301x |
| 通讯作者 | zhang x |
| 中文摘要 | multifunctional nanocarriers based on the up-conversion luminescent nanoparticles of nayf4:yb3+/er3+ core (ucnps) and thermo/ph-coupling sensitive polymer poly[(n-isopropylacrylamide)-co-(methacrylic acid)] (p(nipam-co-maa)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. the as-synthesized hybrid nanospheres ucnps@msio(2)-p(nipam-co-maa) show bright green up-conversion fluorescence under 980 nm laser excitation and the thermo/ph-sensitive polymer is active as a valve to moderate the diffusion of the embedded drugs in-and-out of the pore channels of the silica container. the anticancer drug doxorubicin hydrochloride (dox) can be absorbed into ucnps@msio(2)-p(nipam-co-maa) nanospheres and the composite drug delivery system (dds) shows a low level of leakage at low temperature/high ph values but significantly enhanced release at higher temperature/lower ph values, exhibiting an apparent thermo/ph controlled on-off drug release pattern. the as-prepared ucnps@msio(2)-p(nipam-co-maa) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. the reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli-responsive controlled drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327492300003 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49622]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang X,Yang PP,Dai YL,et al. Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release[J]. advanced functional materials,2013,23(33):4067-4078. |
| APA | Zhang X.,Yang PP.,Dai YL.,Ma PA.,Li XJ.,...&Lin J.(2013).Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release.advanced functional materials,23(33),4067-4078. |
| MLA | Zhang X,et al."Multifunctional Up-Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual-Responsive Drug Controlled Release".advanced functional materials 23.33(2013):4067-4078. |
入库方式： OAI收割
来源：长春应用化学研究所
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