Bioactivity fingerprint analysis of cyclooxygenase-2 ligands from radix Aconiti by ultrafiltration-UPLC-MSn
文献类型：期刊论文
| 作者 | Zhu HB ; Liu S ; Li X ; Song FR ; Liu ZQ ; Liu SY |
| 刊名 | analytical and bioanalytical chemistry
 |
| 出版日期 | 2013 |
| 卷号 | 405期号:23页码:7437-7445 |
| ISSN号 | 1618-2642 |
| 关键词 | TRANSFORM MASS-SPECTROMETRY INHIBITORS CHROMATOGRAPHY ALKALOIDS PRODUCTS QUALITY ACETYLCHOLINESTERASE MEDICINES COX-2 HPLC |
| 通讯作者 | song fr |
| 中文摘要 | a novel fingerprinting method, bioactivity fingerprint analysis, based on an ultrafiltration-ultraperformance liquid chromatography-multistage tandem mass spectrometry (uplc-ms (n) ) method is proposed for the quality control of herbal medicines from the bioactivity viewpoint concerning the efficacy of herbal medicines. the bioactivity fingerprints reflecting the anti-inflammatory activities of radix aconiti and radix aconiti preparata were established. with use of ultrafiltration uplc-ms (n) , 11 cyclooxygenase-2 ligands from radix aconiti preparata and 14 cyclooxygenase-2 ligands from radix aconiti were found after incubation with cyclooxygenase-2. twelve of the cyclooxygenase-2 ligands were identified by the ultraperformance uplc-ms (n) method. the enrichment factor of each peak in the bioactivity fingerprint was calculated and was demonstrated to be characteristic, which makes bioactivity fingerprint analysis for the quality control of herbal medicines possible from the viewpoint of their bioactivities. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000323653400027 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49649]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhu HB,Liu S,Li X,et al. Bioactivity fingerprint analysis of cyclooxygenase-2 ligands from radix Aconiti by ultrafiltration-UPLC-MSn[J]. analytical and bioanalytical chemistry,2013,405(23):7437-7445. |
| APA | Zhu HB,Liu S,Li X,Song FR,Liu ZQ,&Liu SY.(2013).Bioactivity fingerprint analysis of cyclooxygenase-2 ligands from radix Aconiti by ultrafiltration-UPLC-MSn.analytical and bioanalytical chemistry,405(23),7437-7445. |
| MLA | Zhu HB,et al."Bioactivity fingerprint analysis of cyclooxygenase-2 ligands from radix Aconiti by ultrafiltration-UPLC-MSn".analytical and bioanalytical chemistry 405.23(2013):7437-7445. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。