Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells
文献类型：期刊论文
| 作者 | Chen CE ; Zhou L ; Geng J ; Ren JS ; Qu XG |
| 刊名 | small
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:16页码:2793-2800 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES CONTROLLED-RELEASE GUEST MOLECULES TELOMERASE INHIBITION CATIONIC PORPHYRINS CLICK CHEMISTRY PH NANOVALVES BINDING FUNCTIONALIZATION |
| ISSN号 | 1613-6810 |
| 通讯作者 | ren js |
| 中文摘要 | a novel light-operated vehicle for targeted intracellular drug delivery is constructed using photosensitizer-incorporated g-quadruplex dna-capped mesoporous silica nanoparticles. upon light irradiation, the photosensitizer generates ros, causing the dna capping to be cleaved and allowing cargo to be released. importantly, this platform makes it possible to develop a drug-carrier system for the synergistic combination of chemotherapy and pdt for cancer treatment with spatial/temporal control. furthermore, the introducing of targeting ligands further improves tumor targeting efficiency. the excellent biocompatibility, cell-specific intracellular drug delivery, and cellular uptake properties set up the basis for future biomedical application that require in vivo controlled, targeted drug delivery. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327738600019 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49661]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen CE,Zhou L,Geng J,et al. Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells[J]. small,2013,9(16):2793-2800. |
| APA | Chen CE,Zhou L,Geng J,Ren JS,&Qu XG.(2013).Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells.small,9(16),2793-2800. |
| MLA | Chen CE,et al."Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells".small 9.16(2013):2793-2800. |
入库方式： OAI收割
来源：长春应用化学研究所
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