Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions
文献类型：期刊论文
| 作者 | Ding JX ; Xiao CS ; Li YC ; Cheng YL ; Wang NN ; He CL ; Zhuang XL ; Zhu XJ ; Chen XS |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2013 |
| 卷号 | 169期号:3页码:193-203 |
| 关键词 | BLOCK-COPOLYMER MICELLES INTRACELLULAR DRUG-DELIVERY POLY(L-GLUTAMIC ACID) POLYMERIC MICELLES ANTICANCER DRUG POLYPEPTIDE NANOGELS ANTITUMOR-ACTIVITY NANOPARTICLES CANCER TUMOR |
| ISSN号 | 0168-3659 |
| 通讯作者 | zhuang xl |
| 中文摘要 | polymers bearing pendant galactosyl group are attractive for targeted intracellular antitumor drug delivery to hepatoma cells (e. g. hepg2 and smmc7721 cells) with asialoglycoprotein receptor (asgp-r). herein, a series of galactopeptides was synthesized through ring-opening polymerization of l-glutamate n-carboxyanhydride, deprotection of benzyl group and subsequent huisgens cycloaddition "click" reaction with azide-modified galactosyl group. the copolypeptides were revealed to have excellent hemocompatibilities, and cell and tissue compatibilities, which rendered their potential for drug delivery applications. the hepatoma-targeted micellar nanoparticle (i.e. nanomedicine) was fabricated by cooperative self-assembly of galactopeptide and doxorubicin (dox) induced by two-stage physical interactions. in vitro dox release from nanomedicine was accelerated in the intracellular acidic condition. through the recognition between galactose ligand and asgp-r of hepg2 cells, the endocytosis of galactosylated nanomedicine was significantly promoted, which was demonstrated by confocal laser scanning microscopy and flow cytometry. remarkably, the galactose-decorated nanomedicine retained much higher antitumor activity toward hepg2 cells in contrast to the nanomedicine without galactosyl group in vitro and in vivo. the above superiorities indicated that the galactosylated nanomedicine possessed great promising for hepatoma-targeted chemotherapy. (c) 2012 elsevier b. v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000320650500006 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49683]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,Xiao CS,Li YC,et al. Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions[J]. journal of controlled release,2013,169(3):193-203. |
| APA | Ding JX.,Xiao CS.,Li YC.,Cheng YL.,Wang NN.,...&Chen XS.(2013).Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions.journal of controlled release,169(3),193-203. |
| MLA | Ding JX,et al."Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions".journal of controlled release 169.3(2013):193-203. |
入库方式： OAI收割
来源：长春应用化学研究所
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