Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths
文献类型：期刊论文
| 作者 | Li CH ; Wang J |
| 刊名 | plos computational biology
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:8页码:文献号: e1003165 |
| 关键词 | GENE-EXPRESSION POTENTIAL LANDSCAPE STOCHASTICITY ROBUSTNESS PLURIPOTENCY MECHANISMS STABILITY CIRCUITRY DYNAMICS MODEL |
| ISSN号 | 1553-7358 |
| 通讯作者 | li ch |
| 中文摘要 | cellular reprogramming has been recently intensively studied experimentally. we developed a global potential landscape and kinetic path framework to explore a human stem cell developmental network composed of 52 genes. we uncovered the underlying landscape for the stem cell network with two basins of attractions representing stem and differentiated cell states, quantified and exhibited the high dimensional biological paths for the differentiation and reprogramming process, connecting the stem cell state and differentiated cell state. both the landscape and non-equilibrium curl flux determine the dynamics of cell differentiation jointly. flux leads the kinetic paths to be deviated from the steepest descent gradient path, and the corresponding differentiation and reprogramming paths are irreversible. quantification of paths allows us to find out how the differentiation and reprogramming occur and which important states they go through. we show the developmental process proceeds as moving from the stem cell basin of attraction to the differentiation basin of attraction. the landscape topography characterized by the barrier heights and transition rates quantitatively determine the global stability and kinetic speed of cell fate decision process for development. through the global sensitivity analysis, we provided some specific predictions for the effects of key genes and regulation connections on the cellular differentiation or reprogramming process. key links from sensitivity analysis and biological paths can be used to guide the differentiation designs or reprogramming tactics. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000323885400006 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49694]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li CH,Wang J. Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths[J]. plos computational biology,2013,9(8):文献号: e1003165. |
| APA | Li CH,&Wang J.(2013).Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths.plos computational biology,9(8),文献号: e1003165. |
| MLA | Li CH,et al."Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths".plos computational biology 9.8(2013):文献号: e1003165. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。