The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: A PLGA particle system
文献类型：期刊论文
| 作者 | Guo JB ; Li X ; Yu HD ; Tang ZH ; Tang X ; Cai CC ; Xu JH ; Xu H |
| 刊名 | journal of pharmaceutical sciences
 |
| 出版日期 | 2013 |
| 卷号 | 102期号:8页码:2550-2563 |
| 关键词 | LOCAL-DRUG DELIVERY SOLID TUMORS IN-VITRO MELANOMA-CELLS CANCER-THERAPY LIPOSOMES PACLITAXEL NANOPARTICLES CYTOTOXICITY INHIBITOR |
| ISSN号 | 0022-3549 |
| 通讯作者 | xu h |
| 中文摘要 | a dilemma for current cancer therapy is surgical injury in addition to the toxicities and inefficiencies of systemic chemotherapy. meanwhile, localized therapies have become a noticeable strategy. in this study, cucurbitacin (cuc)-loaded poly(lactic-co-glycolic acid) particles of different sizes (about 50 m, 5 m, and 270 nm, respectively) were prepared as the sustained-release system for intratumoral injection, and their physicochemical properties, in vitro cytotoxicity, particles-cells interactions, pharmacokinetics, and pharmacodynamics were systemically investigated for the first time. the results of cytotoxicity experiments and pharmacokinetic/pharmacodynamic studies indicated that the release patterns of the particles would strongly affect the biological efficiency not only at the cell level but also in two types of animal models. cuc raw material and nanoparticles showed higher initial burst release in vitro, and higher drug concentration in tumor and plasma. large particles (about 50 m) showed lower initial burst and slow drug release, which would not supply enough amount of drug to inhibit the cancer cell growth during the whole treatment period. particles with mean diameter of about 5 m performed the best anti-melanoma efficiency both in vitro and in vivo. the release patterns, instead of the particles-cells interactions, would be the key factors to affect the biological effects of the particulate system for intratumoral injection. (c) 2013 wiley periodicals, inc. and the american pharmacists association j pharm sci 102:2550-2563, 2013 |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322991300012 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49699]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo JB,Li X,Yu HD,et al. The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: A PLGA particle system[J]. journal of pharmaceutical sciences,2013,102(8):2550-2563. |
| APA | Guo JB.,Li X.,Yu HD.,Tang ZH.,Tang X.,...&Xu H.(2013).The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: A PLGA particle system.journal of pharmaceutical sciences,102(8),2550-2563. |
| MLA | Guo JB,et al."The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: A PLGA particle system".journal of pharmaceutical sciences 102.8(2013):2550-2563. |
入库方式： OAI收割
来源：长春应用化学研究所
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