Robust and Flexible Free-Standing Films for Unidirectional Drug Delivery
文献类型：期刊论文
| 作者 | Chen DD ; Chen J ; Wu MD ; Tian HY ; Chen XS ; Sun JQ |
| 刊名 | langmuir
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:26页码:8328-8334 |
| 关键词 | POLYELECTROLYTE MULTILAYER FILMS BIOMEDICAL APPLICATIONS MICROGEL FILMS CELL-ADHESION RELEASE NANOPARTICLES SURFACES ASSEMBLIES MEMBRANES COATINGS |
| ISSN号 | 0743-7463 |
| 通讯作者 | sun jq |
| 中文摘要 | robust and flexible free-standing polymer films for unidirectional drug delivery are fabricated by sandwiching drug containing polyelectrolyte multilayer films between poly(lactic-co-glycolic acid) (plga) barrier and capping layers. the drug-containing films are fabricated by layer-by-layer (lbl) assembly of chemically cross-linked poly(allylamine hydrochloride)-dextran (par d) microgel and hyaluronic acid (ha), which can load negatively charged cancer-inhibiting drug, methotrexate (mtx). because the plga barrier layer effectively blocks mtx release, mtx can be predominantly released from the plga capping layer of the free-standing film. this increases the efficacy of released mtx to cancer cells while minimizing its side effects on the normal tissues. we believe that the unidirectional drug delivery free-standing films can open a new avenue to design of highly efficient drug delivery systems for biomedical application. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000321522200018 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49750]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen DD,Chen J,Wu MD,et al. Robust and Flexible Free-Standing Films for Unidirectional Drug Delivery[J]. langmuir,2013,29(26):8328-8334. |
| APA | Chen DD,Chen J,Wu MD,Tian HY,Chen XS,&Sun JQ.(2013).Robust and Flexible Free-Standing Films for Unidirectional Drug Delivery.langmuir,29(26),8328-8334. |
| MLA | Chen DD,et al."Robust and Flexible Free-Standing Films for Unidirectional Drug Delivery".langmuir 29.26(2013):8328-8334. |
入库方式： OAI收割
来源：长春应用化学研究所
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