Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation
文献类型：期刊论文
| 作者 | Li B ; Li TH ; Chen G ; Li XY ; Yan LS ; Xie ZG ; Jing XB ; Huang YB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2013 |
| 卷号 | 13期号:7页码:893-902 |
| 关键词 | OXYGEN CARRIERS BLOCK-COPOLYMER ENCAPSULATION PARTICLES CARBONATE |
| ISSN号 | 1616-5187 |
| 通讯作者 | li th |
| 中文摘要 | amphiphilic triblock copolymers with carbonyl groups located either in the middle segment or in the third side block are synthesized by adjusting feeding sequence of the comonomers. the conjugation of hemoglobin (hb) on the copolymer micelles is realized by condensation reactions of carbonyl with the amino groups of hb, and the gas-binding capacity of hb is well preserved. interestingly, the reassembly behavior of hb-conjugated micelles (hbm) is explored by adjusting the ph. as for triblock copolymers with a carbonyl-functionalized segment as the third block, hb is rearranged into the inner core of micelles when the ph is adjusted close to the isoelectric point of hb. therefore, it may provide a new needed route for fabrication of protein carriers, which is different from the traditional encapsulation technique. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000327814500008 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49751]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li B,Li TH,Chen G,et al. Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation[J]. macromolecular bioscience,2013,13(7):893-902. |
| APA | Li B.,Li TH.,Chen G.,Li XY.,Yan LS.,...&Huang YB.(2013).Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation.macromolecular bioscience,13(7),893-902. |
| MLA | Li B,et al."Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation".macromolecular bioscience 13.7(2013):893-902. |
入库方式： OAI收割
来源：长春应用化学研究所
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