Spiclomazine Induces Apoptosis Associated with the Suppression of Cell Viability, Migration and Invasion in Pancreatic Carcinoma Cells
文献类型：期刊论文
| 作者 | Zhao WJ ; Li D ; Liu ZJ ; Zheng XL ; Wang J ; Wang EK |
| 刊名 | plos one
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:6页码:文献号: e66362 |
| 关键词 | CANCER-CELLS MOLECULAR-MECHANISMS METASTASIS ACTIVATION RESISTANCE INDUCTION PROLIFERATION MITOCHONDRIA STATISTICS PROTEINS |
| ISSN号 | 1932-6203 |
| 通讯作者 | liu zj |
| 中文摘要 | the effective treatment for pancreatic carcinoma remains critically needed. herein, this current study showed that spiclomazine treatment caused a reduction in viability in pancreatic carcinoma cell lines cfpac-1 and mia paca-2 in vitro. it was notable in this regard that, compared with pancreatic carcinoma cells, normal human embryonic kidney (hek-293) and liver (hl-7702) cells were more resistant to the antigrowth effect of spiclomazine. biochemically, spiclomazine treatment regulated the expression of protein levels in the apoptosis related pathways. consistent with this effect, spiclomazine reduced the mitochondria membrane potential, elevated reactive oxygen species, and activated caspase-3/9. in addition, a key finding from this study was that spiclomazine suppressed migration and invasion of cancer cells through down-regulation of mmp-2/9. collectively, the proposed studies did shed light on the antiproliferation effect of spiclomazine on pancreatic carcinoma cell lines, and further clarified the mechanisms that spiclomazine induced apoptosis associated with the suppression of migration and invasion. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322342800052 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49789]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao WJ,Li D,Liu ZJ,et al. Spiclomazine Induces Apoptosis Associated with the Suppression of Cell Viability, Migration and Invasion in Pancreatic Carcinoma Cells[J]. plos one,2013,8(6):文献号: e66362. |
| APA | Zhao WJ,Li D,Liu ZJ,Zheng XL,Wang J,&Wang EK.(2013).Spiclomazine Induces Apoptosis Associated with the Suppression of Cell Viability, Migration and Invasion in Pancreatic Carcinoma Cells.plos one,8(6),文献号: e66362. |
| MLA | Zhao WJ,et al."Spiclomazine Induces Apoptosis Associated with the Suppression of Cell Viability, Migration and Invasion in Pancreatic Carcinoma Cells".plos one 8.6(2013):文献号: e66362. |
入库方式： OAI收割
来源：长春应用化学研究所
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