Regulation of anionic lipids in binary membrane upon the adsorption of polyelectrolyte: A Monte Carlo simulation
文献类型：期刊论文
| 作者 | Duan XZ ; Li YQ ; Zhang R ; Shi TF ; An LJ ; Huang QR |
| 刊名 | aip advances
 |
| 出版日期 | 2013 |
| 卷号 | 3期号:6页码:文献号: 062128 |
| 关键词 | PHOSPHATIDYLINOSITOL 4 PLASMA-MEMBRANE ORDERED MEDIA ELECTROSTATIC INTERACTIONS PROTEIN PIP2 MACROMOLECULES ASSOCIATION DOMAIN BINDING 5-BISPHOSPHATE |
| ISSN号 | 2158-3226 |
| 通讯作者 | shi tf |
| 中文摘要 | we employ monte carlo simulations to investigate the interaction between an adsorbing linear flexible cationic polyelectrolyte and a binary fluid membrane. the membrane contains neutral phosphatidyl-choline, pc) and multivalent anionic (phosphatidylinositol, pip2) lipids. we systematically study the influences of the solution ionic strength, the chain length and the bead charge density of the polyelectrolyte on the lateral rearrangement and the restricted mobility of the multivalent anionic lipids in the membrane. our findings show that, the cooperativity effect and the electrostatic interaction of the polyelectrolyte beads can significantly affect the segregation extent and the concentration gradients of the pip2 molecules, and further cooperate to induce the complicated hierarchical mobility behaviors of pip2 molecules. in addition, when the polyelectrolyte brings a large amount of charges, it can form a robust electrostatic well to trap all pip2 and results in local overcharge of the membrane. this work presents a mechanism to explain the membrane heterogeneity formation induced by the adsorption of charged macromolecule. (c) 2013 author(s). all article content, except where otherwise noted, is licensed under a creative commons attribution 3.0 unported license. [http://dx.doi.org/10.1063/1.4812699] |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000321144300028 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49814]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Duan XZ,Li YQ,Zhang R,et al. Regulation of anionic lipids in binary membrane upon the adsorption of polyelectrolyte: A Monte Carlo simulation[J]. aip advances,2013,3(6):文献号: 062128. |
| APA | Duan XZ,Li YQ,Zhang R,Shi TF,An LJ,&Huang QR.(2013).Regulation of anionic lipids in binary membrane upon the adsorption of polyelectrolyte: A Monte Carlo simulation.aip advances,3(6),文献号: 062128. |
| MLA | Duan XZ,et al."Regulation of anionic lipids in binary membrane upon the adsorption of polyelectrolyte: A Monte Carlo simulation".aip advances 3.6(2013):文献号: 062128. |
入库方式： OAI收割
来源：长春应用化学研究所
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