PLA-PEG-PLA and Its Electroactive Tetraaniline Copolymer as Multi-interactive Injectable Hydrogels for Tissue Engineering
文献类型：期刊论文
| 作者 | Cui HT ; Shao J ; Wang Y ; Zhang PB ; Chen XS ; Wei Y |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2013 |
| 卷号 | 14期号:6页码:1904-1912 |
| 关键词 | BIOMEDICAL APPLICATIONS STEREOCOMPLEX FORMATION ANILINE-PENTAMER BLOCK-COPOLYMERS BIODEGRADABLE HYDROGELS TRIBLOCK COPOLYMER POLYANILINE OLIGOMERS GLYCOL) STIMULATION |
| ISSN号 | 1525-7797 |
| 通讯作者 | chen xs |
| 中文摘要 | injectable hydrogels have served as biomimic scaffolds that provide a three-dimensional (3d) structure for tissue engineering or carriers for cell encapsulation in the biomedical field. in this study, the injectable electroactive hydrogels (iehs) were prepared by introducing electrical properties into the injectable materials. carboxyl-capped tetraaniline (cta) as functional group was coupled with enantiomeric polylactide-poly(ethylene glycol)-polylactide (pla-peg-pla), and the electroactive hydrogels were obtained by mixing the enantiomeric copolymers of cta-plla-peg-plla-cta and cta-pdla-peg-pdla-cta aqueous solutions. ultraviolet-visible spectroscopy (uv-vis) and cyclic voltammetry (cv) of the complex solution showed good electroactive properties. the gelation mechanism and intermolecular multi-interactions such as stereocomplextion, hydrogen bonding, and pi-pi stacking were studied by fourier transform infrared spectroscopy (ft-ir), uv-vis, and wide-angle x-ray diffraction (waxd). gelation properties of the complexes were also studied by rheometer. the encapsulated cells remained highly viable in the gel matrices, suggesting that the hydrogels have excellent cytocompatibility. after subcutaneous injection, the gels were formed in situ in the subcutaneous layer, and hematoxylin-eosin (h&e) staining suggested acceptable biocompatibility of our materials in vivo. moreover, these injectable materials, when treated with pulsed electrical stimuli, were shown to be functionally active and to accelerate the proliferation of encapsulated fibroblasts, cardiomyocytes, and osteoblasts. hence, the iehs possessing these excellent properties would be potentially used as in vivo materials for tissue engineering scaffold. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000320356000022 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49829]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cui HT,Shao J,Wang Y,et al. PLA-PEG-PLA and Its Electroactive Tetraaniline Copolymer as Multi-interactive Injectable Hydrogels for Tissue Engineering[J]. biomacromolecules,2013,14(6):1904-1912. |
| APA | Cui HT,Shao J,Wang Y,Zhang PB,Chen XS,&Wei Y.(2013).PLA-PEG-PLA and Its Electroactive Tetraaniline Copolymer as Multi-interactive Injectable Hydrogels for Tissue Engineering.biomacromolecules,14(6),1904-1912. |
| MLA | Cui HT,et al."PLA-PEG-PLA and Its Electroactive Tetraaniline Copolymer as Multi-interactive Injectable Hydrogels for Tissue Engineering".biomacromolecules 14.6(2013):1904-1912. |
入库方式： OAI收割
来源：长春应用化学研究所
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