The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)
文献类型：期刊论文
| 作者 | Han JD ; Ding JX ; Wang ZC ; Yan SF ; Zhuang XL ; Chen XS ; Yin JB |
| 刊名 | science china-chemistry
 |
| 出版日期 | 2013 |
| 卷号 | 56期号:6页码:729-738 |
| 关键词 | ACID-N-CARBOXYANHYDRIDES HYDROPHILIC BLOCK-COPOLYMERS MOLECULAR-WEIGHT POLY(L-GLUTAMIC ACID) CONTROLLED POLYMERIZATION NCA POLYMERIZATION POLYPEPTIDE DRUG MICELLES INITIATION |
| ISSN号 | 1674-7291 |
| 通讯作者 | chen xs |
| 中文摘要 | diethylamine, di-n-hexylamine, dicyclohexylamine and triethylamine have been used as initiators for the ring-opening polymerization of gamma-benzyl-l-glutamate n-carboxyanhydride (blg nca) to synthesize poly(gamma-benzyl-l-glutamate) (pblg). the relationship between the molecular weight of pblg and the molar ratio of monomer and initiator was studied. with dicyclohexylamine as initiator, the influence of monomer concentration, and reaction temperature and time on the polymerization of blg nca was examined. three reagents were used for the deprotection of benzyl groups in pblg, including hydrobromic acid/acetic acid (33 wt.%), naoh aqueous solution and trimethylsilyl iodide (tmsi). through examining the molecular weight of plga obtained using different deprotection methods, it was revealed that tmsi could minimize chain cleavage in the process of deprotection and retain the degree of polymerization. the biocompatibilities of pblg obtained using different initiators were evaluated by a live/dead assay against l929 fibroblast cells. the in vitro cytotoxicities of plga obtained using different deprotecting agents were evaluated by a methyl thiazolyl tetrazolium assay. the results revealed that both pblg and plga exhibited good biocompatibilities. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319775900005 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49832]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han JD,Ding JX,Wang ZC,et al. The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)[J]. science china-chemistry,2013,56(6):729-738. |
| APA | Han JD.,Ding JX.,Wang ZC.,Yan SF.,Zhuang XL.,...&Yin JB.(2013).The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate).science china-chemistry,56(6),729-738. |
| MLA | Han JD,et al."The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)".science china-chemistry 56.6(2013):729-738. |
入库方式： OAI收割
来源：长春应用化学研究所
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