Luminescent Carbon Dot-Gated Nanovehicles for pH-Triggered Intracellular Controlled Release and Imaging
文献类型：期刊论文
| 作者 | Zhou L ; Li ZH ; Liu Z ; Ren JS ; Qu XG |
| 刊名 | langmuir
 |
| 出版日期 | 2013 |
| 卷号 | 29期号:21页码:6396-6403 |
| 关键词 | RESPONSIVE CONTROLLED-RELEASE CONTROLLED DRUG-RELEASE MESOPOROUS SILICA QUANTUM DOTS MAGNETIC NANOPARTICLES GUEST MOLECULES CARRIER SYSTEM DELIVERY NANOVALVES PROBES |
| ISSN号 | 0743-7463 |
| 通讯作者 | ren js |
| 中文摘要 | in this paper, the use of biocompatible carbon dots (c-dots) as caps on the surface of mesoporous silica nanoparticles (msps) for the design of intelligent on demand molecular delivery and cell imaging system is described. these c-dots-attached msps exhibited low cytotoxicity toward the cells and strong luminescence both in vitro and in vivo. a further loading of anticancer drug (dox) endowed the fluorescent material with therapeutic functions. it was found that changing the ph to mildly acidic condition at physiological temperature caused the dissociation of the c-dots@msps complex and release of a large number of dox from the nanospheres. moreover, the dox-loaded nanocomposites exhibited a remarkably enhanced efficiency in killing cancer cells. the endocytosis and the efficient drug release properties of the system were confirmed by luminescence microscopy. overall, we believe that the well designed c-dots@msps nanocomposites are promising for a simultaneous bioimaging and drug delivery system, which show more potential for clinical application. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319796300024 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49845]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhou L,Li ZH,Liu Z,et al. Luminescent Carbon Dot-Gated Nanovehicles for pH-Triggered Intracellular Controlled Release and Imaging[J]. langmuir,2013,29(21):6396-6403. |
| APA | Zhou L,Li ZH,Liu Z,Ren JS,&Qu XG.(2013).Luminescent Carbon Dot-Gated Nanovehicles for pH-Triggered Intracellular Controlled Release and Imaging.langmuir,29(21),6396-6403. |
| MLA | Zhou L,et al."Luminescent Carbon Dot-Gated Nanovehicles for pH-Triggered Intracellular Controlled Release and Imaging".langmuir 29.21(2013):6396-6403. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。