New views on cellular uptake and trafficking of manufactured nanoparticles
文献类型：期刊论文
| 作者 | Treuel L ; Jiang XE ; Nienhaus GU |
| 刊名 | journal of the royal society interface
 |
| 出版日期 | 2013 |
| 卷号 | 10期号:82页码:文献号: 20120939 |
| 关键词 | RECEPTOR-MEDIATED ENDOCYTOSIS IRON-OXIDE NANOPARTICLES COATED PIT FORMATION GOLD NANOPARTICLES PROTEIN ADSORPTION POLYMERIC NANOPARTICLES BIOMEDICAL APPLICATIONS PENETRATING PEPTIDES SILVER NANOPARTICLES MEMBRANE PENETRATION |
| ISSN号 | 1742-5689 |
| 通讯作者 | nienhaus gu |
| 中文摘要 | nanoparticles (nps) are of similar size to typical cellular components and proteins, and can efficiently intrude living cells. a detailed understanding of the involved processes at the molecular level is important for developing nps designed for selective uptake by specific cells, for example, for targeted drug delivery. in addition, this knowledge can greatly assist in the engineering of nps that should not penetrate cells so as to avoid adverse health effects. in recent years, a wide variety of experiments have been performed to elucidate the mechanisms underlying cellular np uptake. here, we review some select recent studies, which are often based on fluorescence microscopy and sophisticated strategies for specific labelling of key cellular components. we address the role of the protein corona forming around nps in biological environments, and describe recent work revealing active endocytosis mechanisms and pathways involved in their cellular uptake. passive uptake is also discussed. the current state of knowledge is summarized, and we point to issues that still need to be addressed to further advance our understanding of cellular np uptake. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000316415600002 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49870]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Treuel L,Jiang XE,Nienhaus GU. New views on cellular uptake and trafficking of manufactured nanoparticles[J]. journal of the royal society interface,2013,10(82):文献号: 20120939. |
| APA | Treuel L,Jiang XE,&Nienhaus GU.(2013).New views on cellular uptake and trafficking of manufactured nanoparticles.journal of the royal society interface,10(82),文献号: 20120939. |
| MLA | Treuel L,et al."New views on cellular uptake and trafficking of manufactured nanoparticles".journal of the royal society interface 10.82(2013):文献号: 20120939. |
入库方式： OAI收割
来源：长春应用化学研究所
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