Co-delivery of 10-Hydroxycamptothecin with Doxorubicin Conjugated Prodrugs for Enhanced Anticancer Efficacy
文献类型：期刊论文
| 作者 | Zhang Y ; Xiao CS ; Li MQ ; Chen J ; Ding JX ; He CL ; Zhuang XL ; Chen XS |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2013 |
| 卷号 | 13期号:5页码:584-594 |
| 关键词 | IN-VITRO EVALUATION DRUG-DELIVERY BLOCK-COPOLYMER POLY(ETHYLENE OXIDE) ANTITUMOR EFFICACY NANOPARTICLES CAMPTOTHECIN MICELLES THERAPY CELLS |
| ISSN号 | 1616-5187 |
| 通讯作者 | chen xs |
| 中文摘要 | well-defined amphiphilic linear-dendritic prodrugs (mpeg-b-pamam-dox) are synthesized by conjugating doxorubicin (dox), to mpeg-b-pamam through the acid-labile hydrazone bond. the amphiphilic prodrugs form self-assembled nanoparticles in deionized water and encapsulate the hydrophobic anticancer drug 10-hydroxycamptothecin (hcpt) with a high drug loading efficiency. studies on drug release and cellular uptake of the co-delivery system reveal that both drugs are released in a ph-dependent manner and effectively taken up by mcf-7 cells. in vitro methyl thiazolyl tetrazolium (mtt) assays and drug-induced apoptosis tests demonstrate the hcpt-loaded nanoparticles suppress cancer cell growth more efficiently than the mpeg-b-pamam-dox prodrugs, free hcpt, and physical mixtures of mpeg-b-pamam-dox and hcpt at equivalent dox or hcpt doses. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319331100008 |
| 公开日期 | 2014-04-15 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49879]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang Y,Xiao CS,Li MQ,et al. Co-delivery of 10-Hydroxycamptothecin with Doxorubicin Conjugated Prodrugs for Enhanced Anticancer Efficacy[J]. macromolecular bioscience,2013,13(5):584-594. |
| APA | Zhang Y.,Xiao CS.,Li MQ.,Chen J.,Ding JX.,...&Chen XS.(2013).Co-delivery of 10-Hydroxycamptothecin with Doxorubicin Conjugated Prodrugs for Enhanced Anticancer Efficacy.macromolecular bioscience,13(5),584-594. |
| MLA | Zhang Y,et al."Co-delivery of 10-Hydroxycamptothecin with Doxorubicin Conjugated Prodrugs for Enhanced Anticancer Efficacy".macromolecular bioscience 13.5(2013):584-594. |
入库方式： OAI收割
来源：长春应用化学研究所
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