Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy
文献类型：期刊论文
| 作者 | Lai ZZ ; Preketes NK ; Mukamel S ; Wang J |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2013 |
| 卷号 | 117期号:16页码:4661-4669 |
| 关键词 | FEMTOSECOND CORRELATION SPECTROSCOPIES AMIDE-I VIBRATIONAL EXCITONS SECONDARY STRUCTURE MOLECULAR-DYNAMICS ENERGY LANDSCAPE PROTEIN MODEL SIMULATIONS MECHANISM |
| ISSN号 | 1520-6106 |
| 通讯作者 | wang j |
| 中文摘要 | protein folding is one of the most fundamental problems in modern molecular biology. uncovering the detailed folding mechanism requires methods that can monitor the structures at high temporal and spatial resolution. two-dimensional infrared (2dir) spectroscopy is a new tool for studying protein structures and dynamics with high time resolution. using atomistic molecular dynamics simulations, we illustrate the folding process of trp-cage along the dominant pathway on the free energy landscape by analyzing nonchiral and chiral coherent 2dir spectra along the pathway. isotope labeling is used to reveal residue-specific information. we show that the high resolution structural sensitivity of 2dir can differentiate the ensemble evolution of protein and thus provides a microscopic picture of the folding process. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000318211600061 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49896]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lai ZZ,Preketes NK,Mukamel S,et al. Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy[J]. journal of physical chemistry b,2013,117(16):4661-4669. |
| APA | Lai ZZ,Preketes NK,Mukamel S,&Wang J.(2013).Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy.journal of physical chemistry b,117(16),4661-4669. |
| MLA | Lai ZZ,et al."Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy".journal of physical chemistry b 117.16(2013):4661-4669. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。