Identification of polyoxometalates as inhibitors of basic fibroblast growth factor
文献类型：期刊论文
| 作者 | Pu F ; Wang EB ; Jiang HY ; Ren JS |
| 刊名 | molecular biosystems
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:1页码:113-120 |
| 关键词 | HUMAN SERUM-ALBUMIN HEPARIN-BINDING 3-DIMENSIONAL STRUCTURE ANTIANGIOGENIC DRUG RECEPTOR-BINDING ANGIOGENESIS PROTEIN MECHANISMS GLYCOSAMINOGLYCANS PROLIFERATION |
| ISSN号 | 1742-206x |
| 通讯作者 | jiang hy |
| 中文摘要 | angiogenesis is the process of new blood vessel formation from pre-existing ones. angiogenic factors contribute to neovascularization that takes place in angiogenesis-dependent diseases, including cancer. inhibiting the activity of the angiogenic factors to block the angiogenesis pathways is the current strategy of cancer therapy. basic fibroblast growth factor (bfgf) is regarded as one of the most important angiogenic factors. herein, we selected polyoxometalates (poms) with different structures to study the interactions between bfgf and poms. the results show that poms could bind to the protein with high affinity, causing detectable changes in conformation and biophysical properties of protein. in addition, poms could effectively inhibit the cell proliferation induced by bfgf. significantly, we found that the structure, size and composition of poms play a key role in the interactions between bfgf and poms. this study will be meaningful for future screening and design of polyoxometalate-based anticancer drugs. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000311822100013 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49951]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Pu F,Wang EB,Jiang HY,et al. Identification of polyoxometalates as inhibitors of basic fibroblast growth factor[J]. molecular biosystems,2013,9(1):113-120. |
| APA | Pu F,Wang EB,Jiang HY,&Ren JS.(2013).Identification of polyoxometalates as inhibitors of basic fibroblast growth factor.molecular biosystems,9(1),113-120. |
| MLA | Pu F,et al."Identification of polyoxometalates as inhibitors of basic fibroblast growth factor".molecular biosystems 9.1(2013):113-120. |
入库方式： OAI收割
来源：长春应用化学研究所
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