Nanoscaled Poly(L-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer
文献类型：期刊论文
| 作者 | Li MQ ; Song WT ; Tang ZH ; Lv SX ; Lin L ; Sun H ; Li QS ; Yang Y ; Hong H ; Chen XS |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:5页码:1781-1792 |
| 关键词 | IN-VIVO INTRACELLULAR RELEASE MULTIDRUG-RESISTANCE POLYPEPTIDE NANOGELS COPOLYMER MICELLES POLYMERIC MICELLES TRIGGERED RELEASE BLOCK-COPOLYMER DOXORUBICIN NANOPARTICLES |
| ISSN号 | 1944-8244 |
| 通讯作者 | hong h |
| 中文摘要 | nonsmall cell lung cancer (nsclc) is the leading cause of cancer-related death worldwide. herein, we develop a polypeptide-based block ionomer complex formed by anionic methoxy poly(ethylene glycol)-b-poly(l-glutamic acid) (mpeg-b-plg) and cationic anticancer drug doxorubicin hydrochloride (dox center dot hcl) for nsclc treatment. this complex spontaneously self-assembled into spherical nanoparticles (nps) in aqueous solutions via electrostatic interaction and hydrophobic stack, with a high loading efficiency (almost 100%) and negative surface charge. dox center dot hcl release from the drug-loaded micellar nanoparticles (mpeg-b-plg-dox center dot hcl) was slow at physiological ph, but obviously increased at the acidic ph mimicking the endosomal/lysosomal environment. in vitro cytotoxicity and hemolysis assays demonstrated that the block copolypeptide was cytocompatible and hemocompatible, and the presence of copolypeptide carrier could reduce the hemolysis ratio of dox center dot hcl significantly. cellular uptake and cytotoxicity studies suggested that mpeg-b-plg-dox center dot hcl was taken up by a549 cells via endocytosis, with a slightly slower cellular internalization and lower cytotoxicity compared with free dox center dot hcl. the pharmacokinetics study in rats showed that dox center dot hcl-loaded micellar nps significantly prolonged the blood circulation time. moreover, mpeg-b-plg-dox center dot hcl exhibited enhanced therapeutic efficacy, increased apoptosis in tumor tissues, and reduced systemic toxicity in nude mice bearing a549 lung cancer xenograft compared with free dox center dot hcl, which were further confirmed by histological and immunohistochemical analyses. the results demonstrated that mpeg-b-plg was a promising vector to deliver dox center dot hcl into tumors and achieve improved pharmacokinetics, biodistribution and efficacy of dox center dot hcl with reduced toxicity. these features strongly supported the interest of developing mpeg-b-plg-dox center dot hcl as a valid therapeutic modality in the therapy of human nsclc and other solid tumors. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000316308100034 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49978]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li MQ,Song WT,Tang ZH,et al. Nanoscaled Poly(L-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer[J]. acs applied materials & interfaces,2013,5(5):1781-1792. |
| APA | Li MQ.,Song WT.,Tang ZH.,Lv SX.,Lin L.,...&Chen XS.(2013).Nanoscaled Poly(L-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer.acs applied materials & interfaces,5(5),1781-1792. |
| MLA | Li MQ,et al."Nanoscaled Poly(L-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer".acs applied materials & interfaces 5.5(2013):1781-1792. |
入库方式： OAI收割
来源：长春应用化学研究所
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