A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells
文献类型：期刊论文
| 作者 | Li D ; Liu ZJ ; Zhao WJ ; Zheng XL ; Wang J ; Wang EK |
| 刊名 | european journal of pharmaceutical sciences
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:41734页码:658-667 |
| 关键词 | GROWTH-FACTOR RECEPTOR PHASE-III TRIAL CYTOCHROME-C ANTITUMOR-ACTIVITY PLUS GEMCITABINE TYROSINE KINASE BCL-2 FAMILY RAS RESISTANCE THERAPY |
| ISSN号 | 0928-0987 |
| 通讯作者 | wang j |
| 中文摘要 | pancreatic cancer is one of the most malignant tumor diseases with the characters of aggressive growth and metastasis. with the inefficiency of the current therapeutics, new potential targets and new therapeutic agents for healing of pancreatic cancer are critically needed. we have previously found a small molecule, named 4-tert-butyl-2-[(cyclohexylamino) methyl]-6-methylphenol (tbmmp, nsc number: 48160), which can freeze the intermediate of ras-gtp hydrolysis in the open non-signaling conformation with high affinity and high specificity in silico. in this work, we studied the effect and mechanism of tbmmp on two pancreatic cancer cell lines, cfpac-1 and bxpc-3. the results showed that tbmmp could restrain the growth of the pancreatic cancer cells with ic50 value 84.3 mu m for cpfac-1 and 94.5 mu m for bxpc-3, respectively. additionally, tbmmp increased cytochrome c release, reduced mitochondrial membrane potential, activated caspase-3, -9, elevated ros and increased expression of the bax in the pancreatic cancer cell lines. the results indicated that tbmmp induced the apoptosis of pancreatic cancer cells through the mitochondrial pathway. further, we also found that tbmmp could suppress the metastasis of both pancreatic cancer cells in vitro. taken together, we proposed that tbmmp might be a therapeutic potential lead for treating patients with pancreatic cancer. (c) 2013 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000317087300009 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49981]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li D,Liu ZJ,Zhao WJ,et al. A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells[J]. european journal of pharmaceutical sciences,2013,48(41734):658-667. |
| APA | Li D,Liu ZJ,Zhao WJ,Zheng XL,Wang J,&Wang EK.(2013).A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells.european journal of pharmaceutical sciences,48(41734),658-667. |
| MLA | Li D,et al."A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells".european journal of pharmaceutical sciences 48.41734(2013):658-667. |
入库方式： OAI收割
来源：长春应用化学研究所
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