Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation
文献类型：期刊论文
| 作者 | Hu XL ; Yan LS ; Xiao HH ; Li XY ; Jing XB |
| 刊名 | journal of applied polymer science
 |
| 出版日期 | 2013 |
| 卷号 | 127期号:5页码:3365-3373 |
| 关键词 | RING-OPENING POLYMERIZATION AZIDE-ALKYNE CYCLOADDITION PEPTIDE-BASED POLYMERS GEMCITABINE MICELLES MONOMERS DESIGN TAXOL |
| ISSN号 | 0021-8995 |
| 通讯作者 | jing xb |
| 中文摘要 | the aim of this study is to develop azido-carrying biodegradable polymers and their postfunctionalization with alkynyl compounds via click chemistry and to investigate their potential use in drug delivery. azido polymers were prepared by ring-opening polymerization of cyclic carbonate monomer, 2,2-bis(azidomethyl)trimethylene carbonate (atc) with lactide using stannous octoate as catalyst. several alkynyl compounds were selected to investigate the feasibility and reaction condition of click chemistry. with microwave-assisting, the reaction time of click chemistry was shortened to 5 min. by using poly(ethylene glycol) (peg) as macroinitiator, amphiphilic block copolymer mpeg-b-p(la-co-atc) was obtained and it could self-assemble into micelles by solvent replacement method. the pendant groups were used for conjugating anticancer drugs gemcitabine and paclitaxel and fluorescent dye rhodamine b. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to assay the cytotoxicity of the conjugate micelles against skov-3 and hela cell lines. (c) 2012 wiley periodicals, inc. j. appl. polym. sci., 2013 |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000312936400011 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49990]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu XL,Yan LS,Xiao HH,et al. Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation[J]. journal of applied polymer science,2013,127(5):3365-3373. |
| APA | Hu XL,Yan LS,Xiao HH,Li XY,&Jing XB.(2013).Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation.journal of applied polymer science,127(5),3365-3373. |
| MLA | Hu XL,et al."Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation".journal of applied polymer science 127.5(2013):3365-3373. |
入库方式： OAI收割
来源：长春应用化学研究所
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