Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells
文献类型：期刊论文
| 作者 | Zhang YX ; Li QS ; Ge YK ; Chen YP ; Chen J ; Dong Y ; Shi W |
| 刊名 | phytotherapy research
 |
| 出版日期 | 2013 |
| 卷号 | 27期号:3页码:397-403 |
| 关键词 | DOWN-REGULATING SURVIVIN SILYBUM-MARIANUM CANCER CELLS L GAERTN CARCINOMA SILYMARIN P53 INHIBITION EXPRESSION PATHWAY |
| ISSN号 | 0951-418x |
| 通讯作者 | shi w |
| 中文摘要 | silibinin, a flavonoid compound, has shown to be of chemopreventive potential against many cancers. however, its efficacy against gastric cancer has not been well elucidated. here, we assessed the activity of silibinin on apoptosis and cell-cycle arrest in human gastric cells culture system using sgc-7901 as the model. silibinin treatment could inhibit the cell growth and cause a prominent g2 phase arrest and apoptosis in dose- and time-dependent manner. in mechanistic studies, silibinin decreased the protein level of p34cdc2, which might be the possible molecular mechanism of silibinin efficacy on the growth inhibition in sgc-7901 cells. in addition, silibinin caused an increase in p53 and p21 protein level as well as mrna levels. interestingly, silibinin-induced apoptosis in sgc-7901 cells was independent of caspases activation. these results indicated that silibinin is a cell-cycle regulator and apoptosis inducer in human gastric carcinoma sgc-7901 cells and might be used as a candidate chemopreventive agent for gastric carcinoma prevention and intervention. copyright (c) 2012 john wiley & sons, ltd. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000315958400014 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49999]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang YX,Li QS,Ge YK,et al. Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells[J]. phytotherapy research,2013,27(3):397-403. |
| APA | Zhang YX.,Li QS.,Ge YK.,Chen YP.,Chen J.,...&Shi W.(2013).Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells.phytotherapy research,27(3),397-403. |
| MLA | Zhang YX,et al."Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells".phytotherapy research 27.3(2013):397-403. |
入库方式： OAI收割
来源：长春应用化学研究所
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