Long-circulating Gd2O3:Yb3+, Er3+ up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging
文献类型：期刊论文
| 作者 | Liu Z ; Pu F ; Huang S ; Yuan QH ; Ren JS ; Qu XG |
| 刊名 | biomaterials
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:6页码:1712-1721 |
| 关键词 | RAY COMPUTED-TOMOGRAPHY BISMUTH SULFIDE NANOPARTICLES LARGE-SCALE SYNTHESIS IN-VIVO DRUG-DELIVERY SHELL NANOPARTICLES GOLD NANOPARTICLES HEMOLYTIC-ACTIVITY NANOCRYSTALS CT |
| ISSN号 | 0142-9612 |
| 通讯作者 | ren js |
| 中文摘要 | due to their unique electric, magnetic, and optical properties, engineered nanostructures have been applied to provide diagnostic, therapeutic, as well as prognostic information about the status of disease. in this study, we report a multifunctional nanoprobe based on pegylated gd2o3:yb3+, er3+ nanorods (denoted as peg-ucnps) for in vivo up-conversion luminescence (ucl), t-1-enhanced magnetic resonance (mr), and x-ray computed tomography (ct) multi-modality imaging. a facile and large-scale hydrothermal system combining the merits of an in situ thermal decomposition method and a surface-modified approach is introduced to construct high-quality peg-ucnps. by grafting peg molecules on the surface of peg-ucnps, the nanostructures possess excellent stability against in vivo environment and hold long blood circulation time. cell-cytotoxicity assay, hemolyticity, as well as post-injection histology, hematology, and inflammation analysis further demonstrate their non-cytotoxic character and indicate further in vivo application. in detail, the capability of peg-ucnps as high-performance contrast agents for ucl/mr/ct imaging is evaluated successfully through small-animal experiments. additionally, pharmacokinetics, biodistribution, and clearance route are studied after intravenous injection in a mouse model, reflecting their overall safety. (c) 2012 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000315002400007 |
| 公开日期 | 2014-04-16 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/50063]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu Z,Pu F,Huang S,et al. Long-circulating Gd2O3:Yb3+, Er3+ up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging[J]. biomaterials,2013,34(6):1712-1721. |
| APA | Liu Z,Pu F,Huang S,Yuan QH,Ren JS,&Qu XG.(2013).Long-circulating Gd2O3:Yb3+, Er3+ up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging.biomaterials,34(6),1712-1721. |
| MLA | Liu Z,et al."Long-circulating Gd2O3:Yb3+, Er3+ up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging".biomaterials 34.6(2013):1712-1721. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。